PXD006813 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Bladder Tumours O-Glycoproteomics |
Description | Bladder carcinogenesis and tumour progression is accompanied by profound alterations in protein glycosylation. These include the presence of short chain O-glycans such as Tn and T antigens and their sialylated counterparts sialyl-Tn(STn) and sialyl-T(ST). The presence of such structures is commonly associated with poor prognosis. In search for prognosis biomarkers and novel therapeutic targets we have screened, using immunohistochemistry, a series of bladder tumours with differing clinicopathology for these short-chain O-glycans. Aiming at identifying protein targets, we have studied the O-glycoproteome of a pool of STn positive tumours from muscle invasive bladder cancer (MIBC) patients. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:38:23.096.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | André Silva |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | N-acetylhexosaminylated residue; Hex-HexNAc |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-27 07:12:41 | ID requested | |
1 | 2017-08-17 06:56:25 | announced | |
⏵ 2 | 2024-10-22 04:38:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1016/j.jprot.2017.08.004; |
Azevedo R, Silva AMN, Reis CA, Santos LL, Ferreira JA, In silico approaches for unveiling novel glycobiomarkers in cancer. J Proteomics, 171():95-106(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: bladder cancer |
glycoproteomics |
siaic acids |
STn |
Contact List
José Alexandre Ferreira |
contact affiliation | Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Porto, Portugal |
contact email | jose.a.ferreira@ipoporto.min-saude.pt |
lab head | |
André Silva |
contact affiliation | REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Portugal |
contact email | andre.silva@fc.up.pt |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006813
- Label: PRIDE project
- Name: Bladder Tumours O-Glycoproteomics