PXD006813

PXD006813 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Bladder Tumours O-Glycoproteomics
Description	Bladder carcinogenesis and tumour progression is accompanied by profound alterations in protein glycosylation. These include the presence of short chain O-glycans such as Tn and T antigens and their sialylated counterparts sialyl-Tn(STn) and sialyl-T(ST). The presence of such structures is commonly associated with poor prognosis. In search for prognosis biomarkers and novel therapeutic targets we have screened, using immunohistochemistry, a series of bladder tumours with differing clinicopathology for these short-chain O-glycans. Aiming at identifying protein targets, we have studied the O-glycoproteome of a pool of STn positive tumours from muscle invasive bladder cancer (MIBC) patients.
HostingRepository	PRIDE
AnnounceDate	2017-08-17
AnnouncementXML	Submission_2017-08-17_06:56:24.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	André Silva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	N-acetylhexosaminylated; Hex-HexNAc
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-27 07:12:41	ID requested
⏵ 1	2017-08-17 06:56:25	announced

Publication List

Azevedo R, Silva AMN, Reis CA, Santos LL, Ferreira JA, In silico approaches for unveiling novel glycobiomarkers in cancer. J Proteomics, 171():95-106(2018) [pubmed]

Azevedo R, Silva AMN, Reis CA, Santos LL, Ferreira JA, In silico approaches for unveiling novel glycobiomarkers in cancer. J Proteomics, 171():95-106(2018) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: bladder cancer
glycoproteomics
siaic acids
STn

curator keyword: Biomedical

submitter keyword: bladder cancer

glycoproteomics

siaic acids

STn

Contact List

José Alexandre Ferreira
contact affiliation	Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Porto, Portugal
contact email	jose.a.ferreira@ipoporto.min-saude.pt
lab head
André Silva
contact affiliation	REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Portugal
contact email	andre.silva@fc.up.pt
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD006813
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD006813

PRIDE project URI

Repository Record List

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