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PXD006786

PXD006786 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePinctada fucata martensii shell matrix protein LC-MSMS
DescriptionNacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process of matrix-assisted biomineralization. Despite recent advances, many parts of the biomineralization process and its evolutionary origin remain a mystery. The pearl oyster Pinctada fucata martensii is a well-known master of biomineralization, but the molecular mechanisms underlie its production of remarkable shells and pearls is not fully understood. We sequenced the highly polymorphic genome of the pearl oyster and conducted multi-omic and biochemical studies to probe nacre formation. We identified a large set of novel proteins participating in matrix-framework formation, many in expanded families, including components similar to that found in vertebrate bones such as collagen-related VWA-containing proteins (VWAP), chondroitin sulfotransferases and regulatory elements.Considering that there are only collagen-based matrices in vertebrate bones and chitin-based matrices in most invertebrate skeletons, the presence of both chitin and elements of collagen-based matrices in nacre matrices suggests that elements of chitin- and collagen-based matrices are deeply rooted and might be part of an ancient biomineralizing matrix. Our results expand the current shell matrix-framework model and provide new insights into the evolution of diverse biomineralization systems.
HostingRepositoryPRIDE
AnnounceDate2017-07-07
AnnouncementXMLSubmission_2017-09-12_02:39:14.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJie Zhang
SpeciesList scientific name: Bivalvia; NCBI TaxID: 6544;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-06-23 01:27:11ID requested
12017-07-07 07:07:03announced
22017-09-12 02:39:15announcedUpdated publication reference for PubMed record(s): 28873964.
Publication List
Du X, Fan G, Jiao Y, Zhang H, Guo X, Huang R, Zheng Z, Bian C, Deng Y, Wang Q, Wang Z, Liang X, Liang H, Shi C, Zhao X, Sun F, Hao R, Bai J, Liu J, Chen W, Liang J, Liu W, Xu Z, Shi Q, Xu X, Zhang G, Liu X, The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization. Gigascience, 6(8):1-12(2017) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: pearl oyster, shell matrix protein, LC-MSMS
Contact List
Xiaodong Du
contact affiliationKey Laboratory of Aquaculture in South China Sea for Aquatic Economic Animal of Guangdong Higher Education Institutes, Laboratory of Marine Pearl Culture
contact emailzjduxd@126.com
lab head
Jie Zhang
contact affiliationBGI
contact emailzhangjie4@genomics.cn
dataset submitter
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Dataset FTP location
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