PXD006786

PXD006786 is an original dataset announced via ProteomeXchange.

Title	Pinctada fucata martensii shell matrix protein LC-MSMS
Description	Nacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process of matrix-assisted biomineralization. Despite recent advances, many parts of the biomineralization process and its evolutionary origin remain a mystery. The pearl oyster Pinctada fucata martensii is a well-known master of biomineralization, but the molecular mechanisms underlie its production of remarkable shells and pearls is not fully understood. We sequenced the highly polymorphic genome of the pearl oyster and conducted multi-omic and biochemical studies to probe nacre formation. We identified a large set of novel proteins participating in matrix-framework formation, many in expanded families, including components similar to that found in vertebrate bones such as collagen-related VWA-containing proteins (VWAP), chondroitin sulfotransferases and regulatory elements.Considering that there are only collagen-based matrices in vertebrate bones and chitin-based matrices in most invertebrate skeletons, the presence of both chitin and elements of collagen-based matrices in nacre matrices suggests that elements of chitin- and collagen-based matrices are deeply rooted and might be part of an ancient biomineralizing matrix. Our results expand the current shell matrix-framework model and provide new insights into the evolution of diverse biomineralization systems.
HostingRepository	PRIDE
AnnounceDate	2017-07-07
AnnouncementXML	Submission_2017-09-12_02:39:14.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Zhang
SpeciesList	scientific name: Bivalvia; NCBI TaxID: 6544;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-23 01:27:11	ID requested
1	2017-07-07 07:07:03	announced
⏵ 2	2017-09-12 02:39:15	announced	Updated publication reference for PubMed record(s): 28873964.

Du X, Fan G, Jiao Y, Zhang H, Guo X, Huang R, Zheng Z, Bian C, Deng Y, Wang Q, Wang Z, Liang X, Liang H, Shi C, Zhao X, Sun F, Hao R, Bai J, Liu J, Chen W, Liang J, Liu W, Xu Z, Shi Q, Xu X, Zhang G, Liu X, The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization. Gigascience, 6(8):1-12(2017) [pubmed]

curator keyword: Biological

submitter keyword: pearl oyster, shell matrix protein, LC-MSMS

Xiaodong Du
contact affiliation	Key Laboratory of Aquaculture in South China Sea for Aquatic Economic Animal of Guangdong Higher Education Institutes, Laboratory of Marine Pearl Culture
contact email	zjduxd@126.com
lab head
Jie Zhang
contact affiliation	BGI
contact email	zhangjie4@genomics.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD006786

PRIDE project URI

• PRIDE
  1. PXD006786
     1. Label: PRIDE project
     2. Name: Pinctada fucata martensii shell matrix protein LC-MSMS