PXD006781

PXD006781 is an original dataset announced via ProteomeXchange.

Title	Distinct transcriptomic, proteomic and epigenetic stress-responses in dorsal and ventral hippocampus
Description	The hippocampus - one of the most studied brain regions – is a key target of the stress response and vulnerable to the detrimental effects of stress. Although its intrinsic organization is highly conserved throughout its long dorsal-ventral axis, the dorsal hippocampus is linked to spatial navigation and memory formation, whereas the ventral hippocampus is linked to emotional regulation. Here, we provide the first combined transcriptomic and proteomic profiling that reveals striking differences between dorsal and ventral hippocampus. Using various acute stress challenges we demonstrate that both regions display very distinct molecular responses, and that the ventral hippocampus is particularly responsive to the effects of stress. We demonstrate that separately analyzing dorsal and ventral hippocampus greatly increases the ability to detect region-specific stress effects, and we identify an epigenetic network, which is specifically sensitive to acute stress in the ventral hippocampus.
HostingRepository	PRIDE
AnnounceDate	2019-10-03
AnnouncementXML	Submission_2019-10-03_05:03:05.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lukas von Ziegler
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-22 04:30:20	ID requested
⏵ 1	2019-10-03 05:03:07	announced

Floriou-Servou A, von Ziegler L, Stalder L, Sturman O, Privitera M, Rassi A, Cremonesi A, Th, ö, ny B, Bohacek J, Distinct Proteomic, Transcriptomic, and Epigenetic Stress Responses in Dorsal and Ventral Hippocampus. Biol Psychiatry, 84(7):531-541(2018) [pubmed]

curator keyword: Biological

submitter keyword: mouse hippocampus ventral dorsal proteome SWATH-MS stress

Johannes Bohacek
contact affiliation	Swiss Federal Institute of Technology D-HEST
contact email	bohacek@hifo.uzh.ch
lab head
Lukas von Ziegler
contact affiliation	Swiss Federal Institute of Technology
contact email	vonziegler@hifo.uzh.ch
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD006781
     1. Label: PRIDE project
     2. Name: Distinct transcriptomic, proteomic and epigenetic stress-responses in dorsal and ventral hippocampus