PXD006770 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | COPD lungs show an attached stratified mucus layer resembling the protective colonic mucus |
Description | Mucus accumulation is a key feature of respiratory diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). This is associated with goblet cell metaplasia and mucin overexpression, which can be induced by the increased activity of neutrophil elastase. The aim of the study was to characterization of mucus and epithelial cell proteomics in a porcine pancreatic elastase (PPE) mouse model of COPD/CF. The major proteins detected in mucus plugs obtained from PPE-treated mice included mucins Muc5ac and Muc5b, mucus-related proteins Clca1, Fcgbp, and Bpifb1. These proteins were upregulated in bronchoalveolar lavage (BAL) fluid and epithelial cells in mice exposed to elastase. Similar changes were found in BAL fluid of COPD patients. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:46:08.605.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Liisa Arike |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-21 03:46:09 | ID requested | |
1 | 2018-10-22 06:55:36 | announced | |
2 | 2021-09-28 03:22:58 | announced | 2021-09-28: Updated publication reference for PubMed record(s): 30185674. |
⏵ 3 | 2024-10-22 04:46:17 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1172/jci.insight.120994; |
Fern, á, ndez-Blanco JA, Fakih D, Arike L, Rodr, í, guez-Pi, ñ, eiro AM, Mart, í, nez-Abad B, Skansebo E, Jackson S, Root J, Singh D, McCrae C, Evans CM, Å, strand A, Ermund A, Hansson GC, Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. JCI Insight, 3(17):(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: COPD, BAL fluid,Mouse, mucins, human, lungs, PPE, quantitative proteomics, plugs, epithelial cells, LC-MS/MS |
Contact List
Liisa Arike |
contact affiliation | Mucin Biology Group Proteomics Laboratory Department of Medical Biochemistry and Cell Biology University of Gothenburg |
contact email | liisaarike@gmail.com |
lab head | |
Liisa Arike |
contact affiliation | PhD |
contact email | liisaarike@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006770
- Label: PRIDE project
- Name: COPD lungs show an attached stratified mucus layer resembling the protective colonic mucus