PXD006763

PXD006763 is an original dataset announced via ProteomeXchange.

Title	Construction of functional tissue-engineered microvasculatures by using circulating fibrocytes as mural cells
Description	Mural cells are essential to the proper function of microvasculatures. However, the feasible cell source for mural cells has not been found, which is one of the key obstacles facedin tissue engineering. Our data show that circulating fibrocytes (CFs) sheathed and stabilized the microvasculatures formed by vascular endothelial cells (VECs) in collagen gel, formed gap junctions with VECs, and induced formation of basement membrane. When transplanted into nude mice with VECs either in collagen gel or Matrigel, CFs sheathed the microvasculatures formed by VECs, induced basal membrane formation and the microvasculatures connected to the host circulation. Human brain pericytes (HBPCs) had similar function to CFs, but HBPCs often mosaic into the lumen of capillary-like structures, actively proliferate, and have lower capacity of endocytosis and migration. Based on these data, we concluded thatCFs can be used as the cell source for mural cells to generate tissue-engineered microvasculatures
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_07:41:17.501.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinqing Li
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-21 01:29:02	ID requested
⏵ 1	2025-05-06 07:41:18	announced

10.1177/20417314251315523;

curator keyword: Biomedical

submitter keyword: tissue-engineered microvasculatures,circulating fibrocyte

Jinqing Li
contact affiliation	Department of Plastic and Burn Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China
contact email	lijqfmmu@hotmail.com
lab head
Jinqing Li
contact affiliation	Fourth Military Medical University
contact email	lijqfmmu@hotmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD006763
     1. Label: PRIDE project
     2. Name: Construction of functional tissue-engineered microvasculatures by using circulating fibrocytes as mural cells