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PXD006763

PXD006763 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleConstruction of functional tissue-engineered microvasculatures by using circulating fibrocytes as mural cells
DescriptionMural cells are essential to the proper function of microvasculatures. However, the feasible cell source for mural cells has not been found, which is one of the key obstacles facedin tissue engineering. Our data show that circulating fibrocytes (CFs) sheathed and stabilized the microvasculatures formed by vascular endothelial cells (VECs) in collagen gel, formed gap junctions with VECs, and induced formation of basement membrane. When transplanted into nude mice with VECs either in collagen gel or Matrigel, CFs sheathed the microvasculatures formed by VECs, induced basal membrane formation and the microvasculatures connected to the host circulation. Human brain pericytes (HBPCs) had similar function to CFs, but HBPCs often mosaic into the lumen of capillary-like structures, actively proliferate, and have lower capacity of endocytosis and migration. Based on these data, we concluded thatCFs can be used as the cell source for mural cells to generate tissue-engineered microvasculatures
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_07:41:17.501.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJinqing Li
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-06-21 01:29:02ID requested
12025-05-06 07:41:18announced
Publication List
Wang X, Tan H, Gunawardena HP, Cao J, Dang L, Deng H, Li X, Wang H, Li J, Cui C, Gerber DA, Construction of functional tissue-engineered microvasculatures using circulating fibrocytes as mural cells. J Tissue Eng, 16():20417314251315523(2025) [pubmed]
10.1177/20417314251315523;
Keyword List
curator keyword: Biomedical
submitter keyword: tissue-engineered microvasculatures,circulating fibrocyte
Contact List
Jinqing Li
contact affiliationDepartment of Plastic and Burn Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China
contact emaillijqfmmu@hotmail.com
lab head
Jinqing Li
contact affiliationFourth Military Medical University
contact emaillijqfmmu@hotmail.com
dataset submitter
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Dataset FTP location
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