PXD006763 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Construction of functional tissue-engineered microvasculatures by using circulating fibrocytes as mural cells |
Description | Mural cells are essential to the proper function of microvasculatures. However, the feasible cell source for mural cells has not been found, which is one of the key obstacles facedin tissue engineering. Our data show that circulating fibrocytes (CFs) sheathed and stabilized the microvasculatures formed by vascular endothelial cells (VECs) in collagen gel, formed gap junctions with VECs, and induced formation of basement membrane. When transplanted into nude mice with VECs either in collagen gel or Matrigel, CFs sheathed the microvasculatures formed by VECs, induced basal membrane formation and the microvasculatures connected to the host circulation. Human brain pericytes (HBPCs) had similar function to CFs, but HBPCs often mosaic into the lumen of capillary-like structures, actively proliferate, and have lower capacity of endocytosis and migration. Based on these data, we concluded thatCFs can be used as the cell source for mural cells to generate tissue-engineered microvasculatures |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-06 |
AnnouncementXML | Submission_2025-05-06_07:41:17.501.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jinqing Li |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-21 01:29:02 | ID requested | |
⏵ 1 | 2025-05-06 07:41:18 | announced | |
Publication List
Wang X, Tan H, Gunawardena HP, Cao J, Dang L, Deng H, Li X, Wang H, Li J, Cui C, Gerber DA, Construction of functional tissue-engineered microvasculatures using circulating fibrocytes as mural cells. J Tissue Eng, 16():20417314251315523(2025) [pubmed] |
10.1177/20417314251315523; |
Keyword List
curator keyword: Biomedical |
submitter keyword: tissue-engineered microvasculatures,circulating fibrocyte |
Contact List
Jinqing Li |
contact affiliation | Department of Plastic and Burn Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China |
contact email | lijqfmmu@hotmail.com |
lab head | |
Jinqing Li |
contact affiliation | Fourth Military Medical University |
contact email | lijqfmmu@hotmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006763
- Label: PRIDE project
- Name: Construction of functional tissue-engineered microvasculatures by using circulating fibrocytes as mural cells