PXD006755

PXD006755 is an original dataset announced via ProteomeXchange.

Title	human placenta LC-MS/MS .
Description	Hypertensive disorder in pregnancy (HDP) refers to a series of diseases that cause the hypertension during pregnancy, including HDP, preeclampsia (PE) and eclampsia. This study screens differentially expressed proteins of placenta tissues in PE cases using 2D LC-MS/MS quantitative proteomics strategy. A total of 2,281 proteins are quantified, of these, 145 altering expression proteins are successfully screened between PE and control cases (p<0.05). Bioinformatics analysis suggests that these proteins are mainly involved in many biological processes, such as oxidation reduction, mitochondrion organization, and acute inflammatory response. Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFκB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process. Results of this study revealed that glutathione metabolism disorder of placenta tissues may contribute to the occurrence of PE disease.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_10:07:53.674.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaohan Jin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-20 01:46:26	ID requested
⏵ 1	2024-10-07 10:07:54	announced

10.1016/J.BBAPAP.2017.07.003;

curator keyword: Biomedical

submitter keyword: placenta tissue,preeclampsia, quantitative proteomics

Zhongwei Xu
contact affiliation	Tianjin Key Laboratory of Cardiovascular Remodeling & Target Organ Injury, PingjinHospital Heart Center
contact email	xzw113@hotmail.com
lab head
Xiaohan Jin
contact affiliation	Central Laboratory, Logistics University of Chinese People’s Armed Police Force
contact email	cardiolab2016@outlook.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD006755

PRIDE project URI

• PRIDE
  1. PXD006755
     1. Label: PRIDE project
     2. Name: human placenta LC-MS/MS