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PXD006753

PXD006753 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of novel Kv1.3 channel dependent mechanisms in microglial activation
DescriptionPro-inflammatory microglia contribute to disease progression in neuroinflammatory and neurodegenerative diseases. We identify novel Kv1.3 channel-dependent molecular and cellular mechanisms during microglial activation and unravel a Kv1.3-dependent pathway for MHCI-restricted antigen presentation by microglia to CD8+ T cells.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:38:36.853.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEric Dammer
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-06-20 01:32:40ID requested
12018-10-24 11:55:01announced
22024-10-22 04:38:41announced2024-10-22: Updated project metadata.
Publication List
Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI, A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation. J Neuroinflammation, 14(1):128(2017) [pubmed]
10.1186/s12974-017-0906-6;
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: inflammation, potassium channel, systems pharmacology, microglia,BV2
Contact List
Nicholas T. Seyfried
contact affiliationDepartments of Biochemistry and Neurology, Emory University School of Medicine
contact emailnseyfri@emory.edu
lab head
Eric Dammer
contact affiliationEmory University
contact emailedammer@emory.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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