PXD006753 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of novel Kv1.3 channel dependent mechanisms in microglial activation |
Description | Pro-inflammatory microglia contribute to disease progression in neuroinflammatory and neurodegenerative diseases. We identify novel Kv1.3 channel-dependent molecular and cellular mechanisms during microglial activation and unravel a Kv1.3-dependent pathway for MHCI-restricted antigen presentation by microglia to CD8+ T cells. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:38:36.853.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Eric Dammer |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-20 01:32:40 | ID requested | |
1 | 2018-10-24 11:55:01 | announced | |
⏵ 2 | 2024-10-22 04:38:41 | announced | 2024-10-22: Updated project metadata. |
Publication List
Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI, A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation. J Neuroinflammation, 14(1):128(2017) [pubmed] |
10.1186/s12974-017-0906-6; |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: inflammation, potassium channel, systems pharmacology, microglia,BV2 |
Contact List
Nicholas T. Seyfried |
contact affiliation | Departments of Biochemistry and Neurology, Emory University School of Medicine |
contact email | nseyfri@emory.edu |
lab head | |
Eric Dammer |
contact affiliation | Emory University |
contact email | edammer@emory.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD006753 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006753
- Label: PRIDE project
- Name: Identification of novel Kv1.3 channel dependent mechanisms in microglial activation