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PXD006752

PXD006752 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCompartment-resolved proteomic analysis of mouse aorta during atherosclerotic plaque formation
DescriptionAtherosclerosis leads to vascular lesions that involve major rearrangements of the vascular proteome, especially of the extracellular matrix (ECM). Using single aortas from ApoE knock out mice, we quantified formation of plaques by single-run, high-resolution mass spectrometry (MS)-based proteomics. To probe localization on a proteome-wide scale, we employed quantitative detergent solubility profiling. This compartment- and time-resolved resource of atherogenesis comprised 5,117 proteins, 182 of which changed their expression status in response to vessel maturation and atherosclerotic plaque development. In the insoluble ECM proteome, 65 proteins significantly changed, including relevant collagens, matrix metalloproteinases and macrophage specific proteins.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:38:43.802.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Wierer
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-06-20 00:09:08ID requested
12017-12-08 00:35:04announced
22024-10-22 04:38:51announced2024-10-22: Updated project metadata.
Publication List
Wierer M, Prestel M, Schiller HB, Yan G, Schaab C, Azghandi S, Werner J, Kessler T, Malik R, Murgia M, Aherrahrou Z, Schunkert H, Dichgans M, Mann M, Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression. Mol Cell Proteomics, 17(2):321-334(2018) [pubmed]
10.1074/mcp.ra117.000315;
Keyword List
curator keyword: Biomedical
submitter keyword: ECM, mouse model,Atherosclerosis, ApoE, QDSP
Contact List
Matthias Mann
contact affiliationDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany
contact emailmmann@biochem.mpg.de
lab head
Michael Wierer
contact affiliationDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany
contact emailwierer@biochem.mpg.de
dataset submitter
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Dataset FTP location
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