PXD006752 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Compartment-resolved proteomic analysis of mouse aorta during atherosclerotic plaque formation |
Description | Atherosclerosis leads to vascular lesions that involve major rearrangements of the vascular proteome, especially of the extracellular matrix (ECM). Using single aortas from ApoE knock out mice, we quantified formation of plaques by single-run, high-resolution mass spectrometry (MS)-based proteomics. To probe localization on a proteome-wide scale, we employed quantitative detergent solubility profiling. This compartment- and time-resolved resource of atherogenesis comprised 5,117 proteins, 182 of which changed their expression status in response to vessel maturation and atherosclerotic plaque development. In the insoluble ECM proteome, 65 proteins significantly changed, including relevant collagens, matrix metalloproteinases and macrophage specific proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:38:43.802.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michael Wierer |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-20 00:09:08 | ID requested | |
1 | 2017-12-08 00:35:04 | announced | |
⏵ 2 | 2024-10-22 04:38:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
Wierer M, Prestel M, Schiller HB, Yan G, Schaab C, Azghandi S, Werner J, Kessler T, Malik R, Murgia M, Aherrahrou Z, Schunkert H, Dichgans M, Mann M, Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression. Mol Cell Proteomics, 17(2):321-334(2018) [pubmed] |
10.1074/mcp.ra117.000315; |
Keyword List
curator keyword: Biomedical |
submitter keyword: ECM, mouse model,Atherosclerosis, ApoE, QDSP |
Contact List
Matthias Mann |
contact affiliation | Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany |
contact email | mmann@biochem.mpg.de |
lab head | |
Michael Wierer |
contact affiliation | Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany |
contact email | wierer@biochem.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006752
- Label: PRIDE project
- Name: Compartment-resolved proteomic analysis of mouse aorta during atherosclerotic plaque formation