PXD006735

PXD006735 is an original dataset announced via ProteomeXchange.

Title	Remodeling of the Streptococcus mutans proteome in response to LrgAB and external stresses
Description	This project investigates the changes in proteome profiles that occurred in the same set of S. mutans wild-type and lrgAB mutant samples used in our recently published RNA-seq study. To this end, mass spectrometry-based label-free quantitative proteomics, a technology known to enable comprehensive identification and quantification of complete bacterial proteomes, was adapted to study changes in S. mutans intracellular protein levels in response to aeration, heat, and vancomycin stress. Furthermore, the degree of correlation between S. mutans protein abundance profiles and gene expression changes was determined. Further understanding of these combined “-omics” data at the cellular or molecular level will enhance our knowledge of Cid/Lrg-mediated cellular responses of S. mutans to adverse environments. Furthermore, these “-omics” data will serve as a valuable resource that can be mined to help clarify the role of the S. mutans stress response and physiological activity to its dynamic survival in the oral cavity.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:38:26.724.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD006735
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jin Koh
SpeciesList	scientific name: Streptococcus mutans UA159; NCBI TaxID: 210007;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-17 02:03:56	ID requested
1	2018-10-24 12:29:23	announced
⏵ 2	2024-10-22 04:38:27	announced	2024-10-22: Updated project metadata.

10.6019/PXD006735;

10.1038/s41598-017-14324-w;

Ahn SJ, Gu T, Koh J, Rice KC, Remodeling of the Streptococcus mutans proteome in response to LrgAB and external stresses. Sci Rep, 7(1):14063(2017) [pubmed]

curator keyword: Biological

submitter keyword: environment stress, label-free proteomics,Streptococcus mutans

Jin Koh
contact affiliation	Interdisciplinary Center for Biotechnology Research, University of Florida
contact email	jinkoh@ufl.edu
lab head
Jin Koh
contact affiliation	University of Florida
contact email	jinkoh@ufl.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD006735

PRIDE project URI

• PRIDE
  1. PXD006735
     1. Label: PRIDE project
     2. Name: Remodeling of the Streptococcus mutans proteome in response to LrgAB and external stresses