PXD006719

PXD006719 is an original dataset announced via ProteomeXchange.

Title	Breast Cancer Non-Glyco .
Description	Breast cancer is a very common disease in women and its treatment is complicated due to its very heterogeneous nature. The outcome of treatment is consequently highly variable, some patients respond completely to surgical removal of the primary tumour whilst others suffer progression and metastasis regardless of (neo-) adjuvant therapy. Here we present an analysis of a second overlapping set of paired tumours, both synchronous local and asynchronous distant metastases. We show the most significant changes in intracellular protein expression occur in the enzymes involved in pathways of glycoprotein synthesis and decoration during progression, in remodelling of the extra-cellular matrix and in changes in protein translation initiation.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_10:07:41.503.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emila Kurbasic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-14 08:17:53	ID requested
⏵ 1	2024-10-07 10:07:41	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: lymph node metastases, extra-cellular proteins, protein translation, mass spectrometry, membrane proteins, pathway analysis,Breast cancer, biomarkers, protein glycosylation, distant metastases

Peter James
contact affiliation	Lund University, Immunotechnology, LTH
contact email	peter.james@immun.lth.se
lab head
Emila Kurbasic
contact affiliation	Department of Immunotechnology
contact email	emila.kurbasic@immun.lth.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD006719

PRIDE project URI

• PRIDE
  1. PXD006719
     1. Label: PRIDE project
     2. Name: Breast Cancer Non-Glyco