PXD006713

PXD006713 is an original dataset announced via ProteomeXchange.

Title	Quantitative analysis of proteome reveals the roles of Rpd3 and Sir2 in asexual development, virulence and multiple stress responses in Beauveria bassiana.
Description	Lysine acetylation is one of the most prevalent post-translational modifications and has since been found to regulate histone functions and affect chromatin structure and gene expression. Here, we charactered Rpd3, a histone deacetylase of Beauveria bassiana, played important roles in the deacetylation of histone H3 and H4. We unveil the role of Rpd3 in asexual development and show that a ΔRpd3 mutant strain has severe growth defects and is defective in conidiophores and blastospores development. Proteomic analyses indicated that Rpd3 functions in asexual development and virulence and multiple stress responses via broad genetic pathways in B. bassiana. Therefore, we conclude that BbRpd3 is vital for asexual development, virulence and multiple stress responses in Beauveria bassiana.
HostingRepository	PRIDE
AnnounceDate	2021-08-12
AnnouncementXML	Submission_2021-08-12_02:17:28.008.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	QING CAI
SpeciesList	scientific name: Beauveria bassiana ARSEF 2860; NCBI TaxID: 655819;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-14 03:07:03	ID requested
⏵ 1	2021-08-12 02:17:28	announced

Cai Q, Wang ZK, Shao W, Ying SH, Feng MG, Essential role of Rpd3-dependent lysine modification in the growth, development and virulence of Beauveria bassiana. Environ Microbiol, 20(4):1590-1606(2018) [pubmed]

submitter keyword: Beauveria bassiana, rpd3, sir2, proteome, LC-MS/MS.

Mingguang Feng
contact affiliation	Institute of Microbiology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China
contact email	mgfeng@zju.edu.cn
lab head
QING CAI
contact affiliation	Institute of Microbiology, College of Life Sciences, Zhejiang University
contact email	zzucaiqing@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD006713

PRIDE project URI

• PRIDE
  1. PXD006713
     1. Label: PRIDE project
     2. Name: Quantitative analysis of proteome reveals the roles of Rpd3 and Sir2 in asexual development, virulence and multiple stress responses in Beauveria bassiana.