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PXD006675

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2017-11-14
  • AnnouncementXML: Submission_2017-11-14_06:15:26.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Mario Oroshi
  • Title: Region and cell-type resolved quantitative proteomic map of the human heart and its application to atrial fibrillation
  • Description: The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here we determine the healthy human heart proteome by measuring 16 anatomical regions and three major cardiac cell types by high-resolution mass spectrometry-based proteomics. From low microgram sample amounts, we quantified over 11,000 proteins in this high dynamic range tissue. We combined copy numbers per cell with protein organellar assignments to build a model of the heart proteome at the subcellular level. Analysis of cardiac fibroblasts identified 25 cellular receptors as potential new cell surface markers. Application of our heart map to an atrial fibrillation study revealed signatures of distinct mitochondrial dysfunctions. The heart map is available at maxqb.biochem.mpg.de as a resource for future analyses of normal heart function and disease.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: No PTMs are included in the dataset
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02017-06-08 01:30:38ID requested
12017-11-14 06:15:27announced

Publication List

  1. Dataset with its publication pending

Keyword List

  1. curator keyword: Biological, Biomedical
  2. submitter keyword: Heart, mass spectrometry, proteomics

Contact List

    Matthias Mann
    • contact affiliation: Department of Proteomics and Signal Transduction Max-Planck Institute of Biochemistry Germany
    • contact email: mmann@biochem.mpg.de
    • lab head:
    Mario Oroshi
    • contact affiliation: Proteomics
    • contact email: oroshi@biochem.mpg.de
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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