PXD006638

PXD006638 is an original dataset announced via ProteomeXchange.

Title	An OMICS perspective on N-terminal Methionine Excision
Description	Excision of the N-terminal initiator methionine (iMet) from nascent peptide chains is an essential and omnipresent protein modification carried out by Methionine aminopetidases (MetAPs) and accounting for a major source of N-terminal proteoform diversity. While MetAP2 is known to be implicated in processes such as angiogenesis and proliferation in mammals, the physiological role of MetAP1 is much less clear. In this report we studied the omics-wide effects of MetAP1 deletion and MetAP inhibition in general. While the levels of iMet retention are inversely correlated with cellular proliferation rates, deletion of MetAP1 was in part rescued by the increased MetAP2 expression and activity profiles observed.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:37:27.989.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Petra Van Damme
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-01 00:36:00	ID requested
1	2018-01-10 02:44:14	announced
2	2018-01-16 02:43:15	announced	Updated publication reference for PubMed record(s): 29317475.
⏵ 3	2024-10-22 04:37:28	announced	2024-10-22: Updated project metadata.

10.1074/mcp.ra117.000360;

Jonckheere V, Fija, ł, kowska D, Van Damme P, Omics Assisted N-terminal Proteoform and Protein Expression Profiling On Methionine Aminopeptidase 1 (MetAP1) Deletion. Mol Cell Proteomics, 17(4):694-708(2018) [pubmed]

curator keyword: Technical

submitter keyword: MetAP, MetAP1, shotgun, N-terminal proteomics, iMet excision

Petra Van Damme
contact affiliation	VIB-UGent Center for Medical Biotechnology & Department of Biochemistry, Ghent University, Albert Baertsoenkaai 3 9000 Ghent Belgium
contact email	Petra.vandamme@ugent.be
lab head
Petra Van Damme
contact affiliation	University of Ghent
contact email	petra.vandamme@ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD006638

PRIDE project URI

• PRIDE
  1. PXD006638
     1. Label: PRIDE project
     2. Name: An OMICS perspective on N-terminal Methionine Excision