PXD006638 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | An OMICS perspective on N-terminal Methionine Excision |
Description | Excision of the N-terminal initiator methionine (iMet) from nascent peptide chains is an essential and omnipresent protein modification carried out by Methionine aminopetidases (MetAPs) and accounting for a major source of N-terminal proteoform diversity. While MetAP2 is known to be implicated in processes such as angiogenesis and proliferation in mammals, the physiological role of MetAP1 is much less clear. In this report we studied the omics-wide effects of MetAP1 deletion and MetAP inhibition in general. While the levels of iMet retention are inversely correlated with cellular proliferation rates, deletion of MetAP1 was in part rescued by the increased MetAP2 expression and activity profiles observed. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:37:27.989.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Petra Van Damme |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-01 00:36:00 | ID requested | |
1 | 2018-01-10 02:44:14 | announced | |
2 | 2018-01-16 02:43:15 | announced | Updated publication reference for PubMed record(s): 29317475. |
⏵ 3 | 2024-10-22 04:37:28 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1074/mcp.ra117.000360; |
Jonckheere V, Fija, ł, kowska D, Van Damme P, Omics Assisted N-terminal Proteoform and Protein Expression Profiling On Methionine Aminopeptidase 1 (MetAP1) Deletion. Mol Cell Proteomics, 17(4):694-708(2018) [pubmed] |
Keyword List
curator keyword: Technical |
submitter keyword: MetAP, MetAP1, shotgun, N-terminal proteomics, iMet excision |
Contact List
Petra Van Damme |
contact affiliation | VIB-UGent Center for Medical Biotechnology & Department of Biochemistry, Ghent University, Albert Baertsoenkaai 3 9000 Ghent Belgium |
contact email | Petra.vandamme@ugent.be |
lab head | |
Petra Van Damme |
contact affiliation | University of Ghent |
contact email | petra.vandamme@ugent.be |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006638
- Label: PRIDE project
- Name: An OMICS perspective on N-terminal Methionine Excision