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PXD006638

PXD006638 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAn OMICS perspective on N-terminal Methionine Excision
DescriptionExcision of the N-terminal initiator methionine (iMet) from nascent peptide chains is an essential and omnipresent protein modification carried out by Methionine aminopetidases (MetAPs) and accounting for a major source of N-terminal proteoform diversity. While MetAP2 is known to be implicated in processes such as angiogenesis and proliferation in mammals, the physiological role of MetAP1 is much less clear. In this report we studied the omics-wide effects of MetAP1 deletion and MetAP inhibition in general. While the levels of iMet retention are inversely correlated with cellular proliferation rates, deletion of MetAP1 was in part rescued by the increased MetAP2 expression and activity profiles observed.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:37:27.989.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPetra Van Damme
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-06-01 00:36:00ID requested
12018-01-10 02:44:14announced
22018-01-16 02:43:15announcedUpdated publication reference for PubMed record(s): 29317475.
32024-10-22 04:37:28announced2024-10-22: Updated project metadata.
Publication List
10.1074/mcp.ra117.000360;
Jonckheere V, Fija, ł, kowska D, Van Damme P, Omics Assisted N-terminal Proteoform and Protein Expression Profiling On Methionine Aminopeptidase 1 (MetAP1) Deletion. Mol Cell Proteomics, 17(4):694-708(2018) [pubmed]
Keyword List
curator keyword: Technical
submitter keyword: MetAP, MetAP1, shotgun, N-terminal proteomics, iMet excision
Contact List
Petra Van Damme
contact affiliationVIB-UGent Center for Medical Biotechnology & Department of Biochemistry, Ghent University, Albert Baertsoenkaai 3 9000 Ghent Belgium
contact emailPetra.vandamme@ugent.be
lab head
Petra Van Damme
contact affiliationUniversity of Ghent
contact emailpetra.vandamme@ugent.be
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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