PXD006631

PXD006631 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of ethanol tolerance in yeast
Description	For yeast cells, tolerance to high levels of ethanol is vital both in their natural environment and in industrially relevant conditions. We recently genotyped experimentally evolved yeast strains, tolerant to high levels of ethanol. In this study, we elucidate how the genotype and phenotype are related to each other on the molecular level through an integrated analysis of mutation data with protein abundance profiles from six evolved, ethanol-tolerant clones. We constructed a protein network of regulatory proteins, mutated and differentially regulated proteins. This resulted in the identification of a rewired regulatory network after adaptation to high levels of ethanol.
HostingRepository	PRIDE
AnnounceDate	2020-12-03
AnnouncementXML	Submission_2021-07-11_22:24:57.663.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Impens Francis
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-30 23:43:18	ID requested
1	2020-12-02 23:16:04	announced
⏵ 2	2021-07-11 22:24:58	announced	2021-07-12: Updated publication reference for PubMed record(s): 34236875.

Š, o, š, tari, ć N, Arslan A, Carvalho B, Plech M, Voordeckers K, Verstrepen KJ, van Noort V, Integrated Multi-Omics Analysis of Mechanisms Underlying Yeast Ethanol Tolerance. J Proteome Res, 20(8):3840-3852(2021) [pubmed]

curator keyword: Biological

submitter keyword: yeast, ethanol stress, experimental evolution

Kevin Verstrepen
contact affiliation	Lab for Systems Biology, VIB Center for Microbiology KU Leuven Lab for Genetics and Genomics Leuven Institute for Beer Research - LIBR University of Leuven Bio-Incubator Gaston Geenslaan 1 B-3001 Leuven, Belgium
contact email	kevin.verstrepen@kuleuven.vib.be
lab head
Impens Francis
contact affiliation	VIB Proteomics Expertise Center
contact email	francis.impens@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD006631

PRIDE project URI

• PRIDE
  1. PXD006631
     1. Label: PRIDE project
     2. Name: Proteomic profiling of ethanol tolerance in yeast