PXD006587

PXD006587 is an original dataset announced via ProteomeXchange.

Title	Pre-histopathological and sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: a multi-omic analysis
Description	Like many neurological disorders, Alzheimer’s disease has a sex-biased epidemiological profile, affecting approximately twice as many women as men. The cause of this sex difference has yet to be elucidated. To identify molecular correlates of this sex bias, we investigated molecular pathology in females and males using the 5XFAD genetic mouse model of Alzheimer’s disease. We profiled the transcriptome and proteome of the mouse hippocampus during early stages of disease development (1, 2, and 4 months) with RNA-sequencing and Liquid-chromatography mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2018-10-10
AnnouncementXML	Submission_2018-10-10_09:00:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joseph Bundy
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-25 01:20:52	ID requested
⏵ 1	2018-10-10 09:00:56	announced

Bundy JL, Vied C, Badger C, Nowakowski RS, Sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi-omic analysis. J Comp Neurol, 527(2):462-475(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Alzheimer's Disease, Sex differences, Hippocampus, Proteomics, LC-MS/MS

Richard S. Nowakowski
contact affiliation	Department of Biomedical Sciences College of Medicine Florida State University
contact email	richard.nowakowski@med.fsu.edu
lab head
Joseph Bundy
contact affiliation	Florida State University College of Medicine
contact email	josephlbundy@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD006587

PRIDE project URI

• PRIDE
  1. PXD006587
     1. Label: PRIDE project
     2. Name: Pre-histopathological and sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: a multi-omic analysis