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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-10-10
  • AnnouncementXML: Submission_2018-10-10_09:00:55.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Joseph Bundy
  • Title: Pre-histopathological and sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: a multi-omic analysis
  • Description: Like many neurological disorders, Alzheimer’s disease has a sex-biased epidemiological profile, affecting approximately twice as many women as men. The cause of this sex difference has yet to be elucidated. To identify molecular correlates of this sex bias, we investigated molecular pathology in females and males using the 5XFAD genetic mouse model of Alzheimer’s disease. We profiled the transcriptome and proteome of the mouse hippocampus during early stages of disease development (1, 2, and 4 months) with RNA-sequencing and Liquid-chromatography mass spectrometry.
  • SpeciesList: scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
  • ModificationList: phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
  • Instrument: LTQ Orbitrap Velos

Dataset History

VersionDatetimeStatusChangeLog Entry
02017-05-25 01:20:52ID requested
12018-10-10 09:00:56announced

Publication List

  1. Bundy JL, Vied C, Badger C, Nowakowski RS, Sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi-omic analysis. J Comp Neurol, 527(2):462-475(2019) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Alzheimer's Disease, Sex differences, Hippocampus, Proteomics, LC-MS/MS

Contact List

    Richard S. Nowakowski
    • contact affiliation: Department of Biomedical Sciences College of Medicine Florida State University
    • contact email: richard.nowakowski@med.fsu.edu
    • lab head:
    Joseph Bundy
    • contact affiliation: Florida State University College of Medicine
    • contact email: josephlbundy@gmail.com
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List

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