PXD006561

PXD006561 is an original dataset announced via ProteomeXchange.

Title	CDK4/6 inhibitor resistance in prostate cancer
Description	CDK4/6 kinase inhibitors have shown great promise in clinical trials in various cancer types and have recently entered clinical trial for advanced prostate cancer. Although patients are expected to respond well to this class of drugs, development of resistance in some patients is anticipated. To pre-empt this and study how prostate cancer may evade CDK4/6 inhibition, new resistance models were generated from LNCaP and LAPC4 prostate cancer cells cells by prolonged culturing in presence of 0.5uM palbociclib. A shotgun phosphoproteomics approach was utilized and integrated with RNA sequencing data to unravel the molecular underpinnings of acquired resistance to palbociclib and resultant broad CDK4/6 inhibitor resistance.
HostingRepository	PRIDE
AnnounceDate	2018-05-16
AnnouncementXML	Submission_2018-05-16_02:04:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhen Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-22 06:08:19	ID requested
⏵ 1	2018-05-16 02:04:50	announced

de Leeuw R, McNair C, Schiewer MJ, Neupane NP, Brand LJ, Augello MA, Li Z, Cheng LC, Yoshida A, Courtney SM, Hazard ES, Hardiman G, Hussain MH, Diehl JA, Drake JM, Kelly WK, Knudsen KE, MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer. Clin Cancer Res, 24(17):4201-4214(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Prostate cancer, CDK4/6, palbociclib, ribociclib, LNCaP, LAPC4

Justin M. Drake
contact affiliation	Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08901, USA Graduate Program in Cellular and Molecular Pharmacology, Graduate School of Biomedical Sciences, Rutgers
contact email	jd1135@cinj.rutgers.edu
lab head
Zhen Li
contact affiliation	Rutgers Cancer Institute of New Jersey
contact email	zhen.li2000@rutgers.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD006561

PRIDE project URI

• PRIDE
  1. PXD006561
     1. Label: PRIDE project
     2. Name: CDK4/6 inhibitor resistance in prostate cancer