PXD006553

PXD006553 is an original dataset announced via ProteomeXchange.

Title	Altered inflammatory and pro-angiogenic responses caused by imbalanced protection against oxidative stress in endometriosis
Description	Endometriosis is a common gynecological disease of women in reproductive age, and is primarily thought to arise from retrograde menstruation and implantation of endometrium, mostly into the peritoneal cavity. The condition is characterized by a chronic, unresolved inflammatory process, within which oxidative stress likely plays a critical role. Although elevated reactive oxygen species (ROS) and oxidative stress have previously been postulated as being involved in endometriosis pathogenesis, we set out for a more systematic study to identify novel factors defining oxidative stress in ectopic peritoneal lesions. Using combined proteomic and transcriptomic approaches, we identified novel targets, including upregulated pro-oxidative enzymes such as amine oxidase 3/vascular adhesion protein 1 (AOC3/VAP1), as well as downregulated protective factors such as alkenal reductase PTGR1 or methionine sulfoxide reductase, supporting the observation of increased oxidative protein modification in ectopic lesions and peritoneal fluid. The observed ROS-derived 4-hydroxy-2-nonenal-induced interleukin (IL)-8 release from monocytes indicates a further pathomechanism, whereby elevated IL-8 levels promote further immune cell infiltration and angiogenesis in lesions.
HostingRepository	PRIDE
AnnounceDate	2020-05-26
AnnouncementXML	Submission_2020-05-26_11:11:36.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marie-Laëtitia Thézénas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-22 01:48:50	ID requested
⏵ 1	2020-05-26 11:11:37	announced

Th, é, z, é, nas ML, De Leo B, Laux-Biehlmann A, Bafligil C, Elger B, Tapmeier T, Morten K, Rahmioglu N, Dakin SG, Charles P, Martinez FE, Steers G, Fischer OM, Mueller J, Hess-Stumpp H, Steinmeyer A, Manek S, Zondervan KT, Kennedy S, Becker CM, Shang C, Zollner TM, Kessler BM, Oppermann U, Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions. Sci Rep, 10(1):1495(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Endometriosis, LC-MS/MS

Professor Benedikt Kessler
contact affiliation	University of Oxford, NDM Research Building, Target Discovery Institute
contact email	benedikt.kessler@ndm.ox.ac.uk
lab head
Marie-Laëtitia Thézénas
contact affiliation	University of Oxford
contact email	marie-laetitia.thezenas@ndm.ox.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD006553

PRIDE project URI

• PRIDE
  1. PXD006553
     1. Label: PRIDE project
     2. Name: Altered inflammatory and pro-angiogenic responses caused by imbalanced protection against oxidative stress in endometriosis