PXD006553
PXD006553 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Altered inflammatory and pro-angiogenic responses caused by imbalanced protection against oxidative stress in endometriosis |
Description | Endometriosis is a common gynecological disease of women in reproductive age, and is primarily thought to arise from retrograde menstruation and implantation of endometrium, mostly into the peritoneal cavity. The condition is characterized by a chronic, unresolved inflammatory process, within which oxidative stress likely plays a critical role. Although elevated reactive oxygen species (ROS) and oxidative stress have previously been postulated as being involved in endometriosis pathogenesis, we set out for a more systematic study to identify novel factors defining oxidative stress in ectopic peritoneal lesions. Using combined proteomic and transcriptomic approaches, we identified novel targets, including upregulated pro-oxidative enzymes such as amine oxidase 3/vascular adhesion protein 1 (AOC3/VAP1), as well as downregulated protective factors such as alkenal reductase PTGR1 or methionine sulfoxide reductase, supporting the observation of increased oxidative protein modification in ectopic lesions and peritoneal fluid. The observed ROS-derived 4-hydroxy-2-nonenal-induced interleukin (IL)-8 release from monocytes indicates a further pathomechanism, whereby elevated IL-8 levels promote further immune cell infiltration and angiogenesis in lesions. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:04:35.605.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marie-Laëtitia Thézénas |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2017-05-22 01:48:50 | ID requested | |
1 | 2020-05-26 11:11:37 | announced | |
⏵ 2 | 2024-10-22 05:04:43 | announced | 2024-10-22: Updated project metadata. |
Publication List
Th, é, z, é, nas ML, De Leo B, Laux-Biehlmann A, Bafligil C, Elger B, Tapmeier T, Morten K, Rahmioglu N, Dakin SG, Charles P, Martinez FE, Steers G, Fischer OM, Mueller J, Hess-Stumpp H, Steinmeyer A, Manek S, Zondervan KT, Kennedy S, Becker CM, Shang C, Zollner TM, Kessler BM, Oppermann U, Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions. Sci Rep, 10(1):1495(2020) [pubmed] |
10.1038/s41598-020-58362-3; |
Keyword List
curator keyword: Biomedical |
submitter keyword: Endometriosis, LC-MS/MS |
Contact List
Professor Benedikt Kessler | |
---|---|
contact affiliation | University of Oxford, NDM Research Building, Target Discovery Institute |
contact email | benedikt.kessler@ndm.ox.ac.uk |
lab head | |
Marie-Laëtitia Thézénas | |
contact affiliation | University of Oxford |
contact email | marie-laetitia.thezenas@ndm.ox.ac.uk |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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