PXD006543 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A map of protein-metabolite interactions reveals principles of chemical communication |
Description | Application of a novel mass spectrometry-based high-throughput workflow (LiP-SMap) and data resource based on limited proteolysis (LiP) of complex samples. Proteome-wide limited proteolysis sites were obtained in different conditions to infer ligand-induced and protein-protein interaction induced conformational changes. This information was used to identify unknown ligand binding proteins, small molecule-protein binding sites and the remodeling of protein complexes directly in cells. |
HostingRepository | PRIDE |
AnnounceDate | 2018-01-04 |
AnnouncementXML | Submission_2018-01-10_00:45:56.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ilaria Piazza |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion; Q Exactive; Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-05-18 02:10:02 | ID requested | |
1 | 2018-01-04 02:22:59 | announced | |
⏵ 2 | 2018-01-10 00:45:58 | announced | Updated publication reference for PubMed record(s): 29307493. |
Publication List
Piazza I, Kochanowski K, Cappelletti V, Fuhrer T, Noor E, Sauer U, Picotti P, A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication. Cell, 172(1-2):358-372.e23(2018) [pubmed] |
Keyword List
curator keyword: Technical, Biological |
submitter keyword: DIA-MS, small molecules, E.coli, limited proteolysis, LiP-SMap |
Contact List
Paola Picotti |
contact affiliation | Institute of Molecular Systems Biology, ETH Zurich, Switzerland |
contact email | paola.picotti@imsb.biol.ethz.ch |
lab head | |
Ilaria Piazza |
contact affiliation | ETH Zurich |
contact email | ilaria.piazza@bc.biol.ethz.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD006543 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006543
- Label: PRIDE project
- Name: A map of protein-metabolite interactions reveals principles of chemical communication