PXD006479

PXD006479 is an original dataset announced via ProteomeXchange.

Title	Essential proteins' dynamics in Streptococcus sanguinis under antibiotic effect.
Description	The current project investigates the proteomic profiles of essential genes, mass spectrometric analysis respectively, under impact of sub-inhibitory concentration of ampicillin (0.125 micro gm/ml), to elucidate the S. sanguinis stress response mechanisms on a temporal basis and define “pathogenesis signatures” as potential therapeutic targets. We further believe that the current findings will help characterize a bacterial model for studying the dynamics of essential genes under clinically relevant stress factors (antibiotic treatment) and assist in designing evidence-based guidelines for treatment in clinical settings.
HostingRepository	PRIDE
AnnounceDate	2018-01-09
AnnouncementXML	Submission_2018-02-09_11:42:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fadi El-Rami
SpeciesList	scientific name: Streptococcus sanguinis SK36; NCBI TaxID: 388919;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-10 00:08:34	ID requested
1	2018-01-09 08:28:16	announced
⏵ 2	2018-02-09 11:42:19	announced	Updated publication reference for PubMed record(s): 29393020.

El-Rami F, Kong X, Parikh H, Zhu B, Stone V, Kitten T, Xu P, Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis. Microbiology (Reading), 164(2):173-185(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Streptococcus sanguinis, essential genes, antibiotic, oral, stress

Ping Xu
contact affiliation	Ping Xu, Professor VCU Philips Institute for Oral Health Research Microbiology and Immunology Virginia Commonwealth University Phone: 804-827-6264 Fax: 804-828-0150
contact email	pxu@vcu.edu
lab head
Fadi El-Rami
contact affiliation	Virginia Commonwealth University
contact email	elramif@vcu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD006479

PRIDE project URI

• PRIDE
  1. PXD006479
     1. Label: PRIDE project
     2. Name: Essential proteins' dynamics in Streptococcus sanguinis under antibiotic effect.