PXD006455

PXD006455 is an original dataset announced via ProteomeXchange.

Title	HLA-C*05:01 and HLA-C*07:02 from 721.221 cells
Description	HLA-C expresion varies widely across the different HLA-C alleles. MicroRNA binding can partly explain the differences in HLA-C allele expression however other contributing factors still remain undetermined. Here we use two common HLA-C alleles, HLA-C*05:01 and HLA-C*07:02, to explore differences in expression levels. Using functional, structural and peptide repertoire comparisons we demonstrate that HLA-C expression levels are not only modulated at the RNA level but also at the protein level. This dataset contains RAW data and database search results for HLA-C*05:01 and HLA-C*07:02 from the 721.221 cell line.
HostingRepository	PRIDE
AnnounceDate	2017-07-03
AnnouncementXML	Submission_2017-07-02_23:51:00.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jesse Mobbs
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-05 00:46:30	ID requested
⏵ 1	2017-07-02 23:51:02	announced

Kaur G, Gras S, Mobbs JI, Vivian JP, Cortes A, Barber T, Kuttikkatte SB, Jensen LT, Attfield KE, Dendrou CA, Carrington M, McVean G, Purcell AW, Rossjohn J, Fugger L, Structural and regulatory diversity shape HLA-C protein expression levels. Nat Commun, 8():15924(2017) [pubmed]

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

curator keyword: Biological

submitter keyword: Human, HLA Class I, HLA-C

Anthony W Purcell
contact affiliation	Professor Anthony W Purcell Deputy Head (Research), Department of Biochemistry and Molecular Biology Head Immunoproteomics Laboratory Monash University, Clayton Campus Clayton 3800 Victoria Australia
contact email	anthony.purcell@monash.edu
lab head
Jesse Mobbs
contact affiliation	Monash University
contact email	jesse.mobbs@monash.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD006455

PRIDE project URI

• PRIDE
  1. PXD006455
     1. Label: PRIDE project
     2. Name: HLA-C*05:01 and HLA-C*07:02 from 721.221 cells