PXD006439

PXD006439 is an original dataset announced via ProteomeXchange.

Title	Signaling networks transported by EVs drive phenocopying of migratory behavior between tumor cells
Description	Tumors are heterogeneous with respect to mutational pattern, gene expression and microenvironment. This heterogeneity leads to large functional intratumoral differences in tumor cell behavior so that a tumor may contain or develop small fractions of cells that possess properties to migrate, metastasize or evade therapy treatment. In recent years, extracellular vesicles (EVs) have attracted a lot of attention as microenvironmental intercellular messenger that may severely complicate tumor heterogeneity. EVs are small lipid membrane-enclosed vesicles that carry biologically active molecules including lipids, proteins, DNA and various RNA species. Although accumulating evidence suggest that tumor cells can phenocopy behavior through exchange of EVs, it is widely debated how the transfer of small amounts of cargo can mediate this effect. We isolated EVs from tumors grown in mice and identified that sub tumor clones with distinct metastatic potential transfer networks of RNAs and proteins involved in migration, and leads to phenocopying of migratory behavior.
HostingRepository	PRIDE
AnnounceDate	2018-06-22
AnnouncementXML	Submission_2018-06-22_02:26:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sander Piersma
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	amidated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-03 05:20:31	ID requested
⏵ 1	2018-06-22 02:26:07	announced

Steenbeek SC, Pham TV, de Ligt J, Zomer A, Knol JC, Piersma SR, Schelfhorst T, Huisjes R, Schiffelers RM, Cuppen E, Jimenez CR, van Rheenen J, Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. EMBO J, 37(15):(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: EV, extracellular vesicle, label-free, tumor

Connie Ramona Jimenez
contact affiliation	OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
contact email	c.jimenez@vumc.nl
lab head
Sander Piersma
contact affiliation	OncoProteomics Laboratory, dept of Medical Oncology, VUmc Medical Center, Amsterdam, The Netherlands
contact email	s.piersma@vumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD006439

PRIDE project URI

• PRIDE
  1. PXD006439
     1. Label: PRIDE project
     2. Name: Signaling networks transported by EVs drive phenocopying of migratory behavior between tumor cells