PXD006397

PXD006397 is an original dataset announced via ProteomeXchange.

Title	Cell-intrinsic regulation of interneuron migration controls cortical neurogenesis
Description	Interneurons navigate along multiple tangential paths to settle into appropriate cortical layer. They undergo saltatory migration, which is paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. However, it remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes deglutamylation, is a pivotal regulator of pausing of cortical interneurons. Moreover, we show that pausing during migration controls the flow of interneurons invading the cortex by generating heterogeinity in movement at the population level. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also secondarily impairs the generation of age-matched upper layer projection neurons.
HostingRepository	PRIDE
AnnounceDate	2018-02-14
AnnouncementXML	Submission_2019-02-12_08:20:32.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sebastian Tanco
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-27 03:23:30	ID requested
1	2018-02-14 06:58:46	announced
⏵ 2	2019-02-12 08:20:34	announced	Updated publication reference for PubMed record(s): 29474907.

Silva CG, Peyre E, Adhikari MH, Tielens S, Tanco S, Van Damme P, Magno L, Krusy N, Agirman G, Magiera MM, Kessaris N, Malgrange B, Andrieux A, Janke C, Nguyen L, Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell, 172(5):1063-1078.e19(2018) [pubmed]

curator keyword: Biological

submitter keyword: CCP1, deglutamylation, interneuron, migration

Petra Van Damme
contact affiliation	VIB-UGent Center for Medical Biotechnology, Ghent, Belgium
contact email	petra.vandamme@vib-ugent.be
lab head
Sebastian Tanco
contact affiliation	Department of Medical Protein Research, VIB-Ghent University
contact email	sebastian.tanco@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD006397

PRIDE project URI

• PRIDE
  1. PXD006397
     1. Label: PRIDE project
     2. Name: Cell-intrinsic regulation of interneuron migration controls cortical neurogenesis