PXD006362

PXD006362 is an original dataset announced via ProteomeXchange.

Title	PGC7-interacting proteins in HEK293T cells
Description	Primordial germ cell 7 (PGC7), a maternal factor essential for early development, plays a critical role in the regulation of DNA methylation, transcriptional repression, chromatin condensation, and cell division and the maintenance of cell pluripotentiality. Despite the fundamental roles of PGC7 in these cellular processes, only a few molecular and functional interactions of PGC7 have been reported. Here, a streptavidin–biotin affinity purification technique combined with LC−MS/MS was used to analyze potential proteins that interact with PGC7. In total, 291 potential PGC7-interacting proteins were identified.Knowledge of these new PGC7-interacting proteins will likely explain the findings of previous studies on PGC7 and provide a substantial resource for subsequent in-depth studies on PGC7 functions.
HostingRepository	PRIDE
AnnounceDate	2017-07-28
AnnouncementXML	Submission_2017-07-28_08:03:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liu Hongliang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-24 04:29:45	ID requested
⏵ 1	2017-07-28 08:03:07	announced

Liu H, Zhang L, Wei Q, Shi Z, Shi X, Du J, Huang C, Zhang Y, Guo Z, Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. J Proteome Res, 16(9):3113-3123(2017) [pubmed]

curator keyword: Biological

submitter keyword: PGC7;HEK293T;LC-MS/MS

Guo Zekun
contact affiliation	1,College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China 2,Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi 712100, China
contact email	gzk@nwsuaf.edu.cn
lab head
Liu Hongliang
contact affiliation	College of Veterinary Medicine, Northwest A&F University
contact email	liuhl355113@sina.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD006362

PRIDE project URI

• PRIDE
  1. PXD006362
     1. Label: PRIDE project
     2. Name: PGC7-interacting proteins in HEK293T cells