PXD006356

PXD006356 is an original dataset announced via ProteomeXchange.

Title	Rat podocyte degradomics
Description	Regulated intracellular proteolysis is essential in maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. Altered proteolytic substrate turnover has been associated with various glomerular diseases ranging from diabetic nephropathy to focal and segmental glomerulosclerosis. However, thus far it has not been possible to systematically identify proteolytically cleaved proteins although some of the proteases have been characterized. Here we applied TAILS to identify N-termini in rat glomeruli and their changes on PAN-induced injury.
HostingRepository	PRIDE
AnnounceDate	2017-07-20
AnnouncementXML	Submission_2017-07-21_00:39:20.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pitter Huesgen
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	carbamoylated residue; monohydroxylated residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-24 00:27:29	ID requested
1	2017-07-20 04:07:14	announced
⏵ 2	2017-07-21 00:39:22	announced	Updated publication reference for PubMed record(s): 28724775.

Rinschen MM, Hoppe AK, Grahammer F, Kann M, V, ö, lker LA, Schurek EM, Binz J, H, ö, hne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T, N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton. J Am Soc Nephrol, 28(10):2867-2878(2017) [pubmed]

curator keyword: Biological

submitter keyword: rat, glomeruli, LC-MS/MS, TAILS

Pitter Huesgen
contact affiliation	Forschugnszentrum Jülich ZEA-3 Analytics Wilhelm-Johnen-Str 52425 Jülich Germany
contact email	p.huesgen@fz-juelich.de
lab head
Pitter Huesgen
contact affiliation	Forschungszentrum Jülich
contact email	p.huesgen@fz-juelich.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD006356

PRIDE project URI

• PRIDE
  1. PXD006356
     1. Label: PRIDE project
     2. Name: Rat podocyte degradomics