PXD006350

PXD006350 is an original dataset announced via ProteomeXchange.

Title	Target proteins of miR-200b in AIPC by label free proteomics
Description	For androgen-independent prostate cancer (AIPC), the current treatment is limited and the prognosis is poor. We previously found miR-200b could inhibit androgen independent proliferation ability of prostate cancer cells, but the mechanism is unclear. MiRNAs plays their role by blocking translation through base-pairing with complementary mRNA and by promoting degradation of target mRNA. Unraveling the miRNA translational silencing network remains a challenge in part because a single miRNA can inhibit multiple mRNA targets and because a single mRNA can be regulated by several distinct miRNAs that act cooperatively. However, proteomics methods provide us useful tools to unravel the target genes network. This study identified the target genes of miR-200b in AIPC. It helps us to understand the mechanism of AIPC and applies several new candidate targets of AIPC treatment.
HostingRepository	PRIDE
AnnounceDate	2020-08-05
AnnouncementXML	Submission_2020-08-04_23:09:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yawei Liu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-21 07:57:25	ID requested
⏵ 1	2020-08-04 23:09:34	announced

Xinqiang S, Erqin D, Yu Z, Hongtao D, Lei W, Ningning Y, Potential mechanisms of action of celastrol against rheumatoid arthritis: Transcriptomic and proteomic analysis. PLoS One, 15(7):e0233814(2020) [pubmed]

curator keyword: Biological

submitter keyword: prostate cancer, androgen-independent prostate cancer, miR-200b, proteomics

Yawei Liu
contact affiliation	Department of Neurosurgery, Nanfang hospital, Southern Medical University, Guangzhou 510515,China
contact email	liuyawei@smu.edu.cn
lab head
Yawei Liu
contact affiliation	Department of Neurosurgery, Nanfang hospital, Southern Medical University, Guangzhou 510515,China
contact email	liuyawei@smu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/08/PXD006350

PRIDE project URI

• PRIDE
  1. PXD006350
     1. Label: PRIDE project
     2. Name: Target proteins of miR-200b in AIPC by label free proteomics