PXD006349 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats |
Description | In order to better understand physiological mechanisms and neurological symptoms involved in the development of decompression sickness we determined effects in rats on the brain proteome of fast decompression (1 bar/20 s) compared to controls (1 bar/10 min) after heliox saturation diving. The orbitrap LC-MS/MS data files presented here resulted in 1062 proteins quantified using label-free proteomics. Based on the 128 significantly regulated proteins in the orbitrap dataset and 56 in an iontrap dataset (967 quantified proteins), the networks “synaptic vesicle fusion and recycling in nerve terminals” and “translation initiation” were significantly enriched in a system biological database analysis (Metacore). Ribosomal proteins (RLA2, RS10) and the proteins hippocalcin-like protein 4 and proteasome subunit beta type-7 were significantly upregulated in both datasets. The heat shock protein 105 kDa, Rho-associated protein kinase 2 and Dynamin-1 were significantly downregulated in both datasets. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:36:57.112.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alvhild Alette Bjoerkum |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-04-21 07:50:43 | ID requested | |
1 | 2017-10-09 23:56:06 | announced | |
⏵ 2 | 2024-10-22 04:37:00 | announced | 2024-10-22: Updated project metadata. |
Publication List
Bj, ø, rkum AA, Oveland E, Stuhr L, Havnes MB, Berven F, Gr, ø, nning M, Hope A, Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats. PLoS One, 12(10):e0185765(2017) [pubmed] |
10.1371/journal.pone.0185765; |
Keyword List
curator keyword: Biological |
submitter keyword: cytoskeleton, synaptic vesicle, fast decompression, label-free proteomics, S100B,Diving, translation initiation, heliox saturation, ribosomal proteins |
Contact List
Alvhild Alette Bjørkum |
contact affiliation | Associate professor, Department of Biomedical laboratory sciences and chemical engineering, Bergen University College, Bergen, Norway. |
contact email | Alvhild.Bjorkum@hib.no |
lab head | |
Alvhild Alette Bjoerkum |
contact affiliation | Bergen University College |
contact email | Alvhild.Bjorkum@hib.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006349
- Label: PRIDE project
- Name: Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats