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PXD006349

PXD006349 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFast hyperbaric decompression after heliox saturation altered the brain proteome in rats
DescriptionIn order to better understand physiological mechanisms and neurological symptoms involved in the development of decompression sickness we determined effects in rats on the brain proteome of fast decompression (1 bar/20 s) compared to controls (1 bar/10 min) after heliox saturation diving. The orbitrap LC-MS/MS data files presented here resulted in 1062 proteins quantified using label-free proteomics. Based on the 128 significantly regulated proteins in the orbitrap dataset and 56 in an iontrap dataset (967 quantified proteins), the networks “synaptic vesicle fusion and recycling in nerve terminals” and “translation initiation” were significantly enriched in a system biological database analysis (Metacore). Ribosomal proteins (RLA2, RS10) and the proteins hippocalcin-like protein 4 and proteasome subunit beta type-7 were significantly upregulated in both datasets. The heat shock protein 105 kDa, Rho-associated protein kinase 2 and Dynamin-1 were significantly downregulated in both datasets.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:36:57.112.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlvhild Alette Bjoerkum
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-04-21 07:50:43ID requested
12017-10-09 23:56:06announced
22024-10-22 04:37:00announced2024-10-22: Updated project metadata.
Publication List
Bj, ø, rkum AA, Oveland E, Stuhr L, Havnes MB, Berven F, Gr, ø, nning M, Hope A, Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats. PLoS One, 12(10):e0185765(2017) [pubmed]
10.1371/journal.pone.0185765;
Keyword List
curator keyword: Biological
submitter keyword: cytoskeleton, synaptic vesicle, fast decompression, label-free proteomics, S100B,Diving, translation initiation, heliox saturation, ribosomal proteins
Contact List
Alvhild Alette Bjørkum
contact affiliationAssociate professor, Department of Biomedical laboratory sciences and chemical engineering, Bergen University College, Bergen, Norway.
contact emailAlvhild.Bjorkum@hib.no
lab head
Alvhild Alette Bjoerkum
contact affiliationBergen University College
contact emailAlvhild.Bjorkum@hib.no
dataset submitter
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Dataset FTP location
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