PXD006349

PXD006349 is an original dataset announced via ProteomeXchange.

Title	Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats
Description	In order to better understand physiological mechanisms and neurological symptoms involved in the development of decompression sickness we determined effects in rats on the brain proteome of fast decompression (1 bar/20 s) compared to controls (1 bar/10 min) after heliox saturation diving. The orbitrap LC-MS/MS data files presented here resulted in 1062 proteins quantified using label-free proteomics. Based on the 128 significantly regulated proteins in the orbitrap dataset and 56 in an iontrap dataset (967 quantified proteins), the networks “synaptic vesicle fusion and recycling in nerve terminals” and “translation initiation” were significantly enriched in a system biological database analysis (Metacore). Ribosomal proteins (RLA2, RS10) and the proteins hippocalcin-like protein 4 and proteasome subunit beta type-7 were significantly upregulated in both datasets. The heat shock protein 105 kDa, Rho-associated protein kinase 2 and Dynamin-1 were significantly downregulated in both datasets.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:36:57.112.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alvhild Alette Bjoerkum
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-21 07:50:43	ID requested
1	2017-10-09 23:56:06	announced
⏵ 2	2024-10-22 04:37:00	announced	2024-10-22: Updated project metadata.

Bj, ø, rkum AA, Oveland E, Stuhr L, Havnes MB, Berven F, Gr, ø, nning M, Hope A, Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats. PLoS One, 12(10):e0185765(2017) [pubmed]

10.1371/journal.pone.0185765;

curator keyword: Biological

submitter keyword: cytoskeleton, synaptic vesicle, fast decompression, label-free proteomics, S100B,Diving, translation initiation, heliox saturation, ribosomal proteins

Alvhild Alette Bjørkum
contact affiliation	Associate professor, Department of Biomedical laboratory sciences and chemical engineering, Bergen University College, Bergen, Norway.
contact email	Alvhild.Bjorkum@hib.no
lab head
Alvhild Alette Bjoerkum
contact affiliation	Bergen University College
contact email	Alvhild.Bjorkum@hib.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD006349

PRIDE project URI

• PRIDE
  1. PXD006349
     1. Label: PRIDE project
     2. Name: Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats