PXD006314

PXD006314 is an original dataset announced via ProteomeXchange.

Title	HIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~90% cell culture confluence dataset)
Description	We have used LC-MSMS discovery proteomics to identify the quantitative, cell-wide changes that occur when non-transformed, differentiated human neurons are treated with HIV-Tat over time. This may represent a novel cell culture model for initial HIV-associated neurocognitive disorder progression.
HostingRepository	PRIDE
AnnounceDate	2017-05-19
AnnouncementXML	Submission_2017-06-20_05:42:03.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kim Gurwitz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-18 01:49:29	ID requested
1	2017-05-19 02:12:50	announced
⏵ 2	2017-06-20 05:42:04	announced	Updated publication reference for PubMed record(s): 28611588.

Gurwitz KT, Burman RJ, Murugan BD, Garnett S, Ganief T, Soares NC, Raimondo JV, Blackburn JM, : Towards a Model for the Molecular Pathology of HIV-Associated Neurocognitive Disorders. Front Mol Neurosci, 10():163(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: Human neuronal cells, HIV-Tat, HIV associated neurocognitive disorders, LCMSMS

Prof. Jonathan Blackburn
contact affiliation	Department of Integrative Biomedical Science, Blackburn Group, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
contact email	jonathan.blackburn@uct.ac.za
lab head
Kim Gurwitz
contact affiliation	University of Cape Town
contact email	kgurwitz@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/05/PXD006314

PRIDE project URI

• PRIDE
  1. PXD006314
     1. Label: PRIDE project
     2. Name: HIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~90% cell culture confluence dataset)