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PXD006293 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMulti-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
DescriptionMitonuclear communication is essential to maintain cellular and organismal homeostasis in equilibrium and stress. Mitochondrial stress activates a concerted mitonuclear response geared to safeguard and repair mitochondrial function and to adapt cellular metabolism to the stress. However, the common mediator driving this stress response in mammals remains elusive. By using a multi-omics approach we identify that the activating transcription factor 4 (ATF4) is the main player regulating this response. ATF4 activates the expression of cytoprotective genes, which reprogram cellular metabolism, through activation of the integrated stress response (ISR). Mitochondrial stress also promotes a local proteostatic response, by inducing a decrease in mitochondrial ribosomal proteins, inhibiting mitochondrial translation and coupling as such the activation of the ISR with the attenuation of mitochondrial function. Our data illustrate the value of a multi-omics approach to characterize complex cellular networks and provide a versatile resource to identify new regulators of mitochondrial-related diseases.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMiguel Prado
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-04-13 06:51:48ID requested
12017-06-01 06:04:19announced
22017-06-07 00:19:00announcedUpdated publication reference for PubMed record(s): 28566324.
Publication List
QuirĂ³s PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J, Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. J Cell Biol, 216(7):2027-2045(2017) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: mitochondria, ATF4, omics, human, Orbitral Fusion
Contact List
Daniel J Finley
contact affiliationFinley and Gygi lab Cell Biology Department Harvard Medical School US
contact emaildaniel_finley@hms.harvard.edu
lab head
Miguel Prado
contact affiliationHarvard Medical School
contact emailmiguel_prado@hms.harvard.edu
dataset submitter
Full Dataset Link List
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PRIDE project URI
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