PXD006290

PXD006290 is an original dataset announced via ProteomeXchange.

Title	Cross talks between mutant Leucine Rich Repeat Kinase 2 in the peripheral immune system and the CNS regulate neurodegeneration after environmental insult - part 1
Description	Missense mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene result in late-onset Parkinson’s disease (PD). The incomplete penetrance of LRRK2 mutations in humans and LRRK2 murine models of PD suggests that the disease may result from a complex interplay of genetic predispositions and persistent exogenous insults. To achieve a detailed characterization of the altered neuroinflammatory reaction in the brain of mutant LRRK2 mice, we performed mass spectrometry analysis (tandem mass tagging, TMT) of brain tissue obtained from intact and acute LPS-challenged WT and R1441G mutant mice.
HostingRepository	PRIDE
AnnounceDate	2018-05-03
AnnouncementXML	Submission_2018-06-07_00:27:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Timothy Shaw
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-13 06:34:43	ID requested
1	2018-05-02 23:41:15	announced
⏵ 2	2018-06-07 00:27:55	announced	Updated publication reference for PubMed record(s): 29800472.

Kozina E, Sadasivan S, Jiao Y, Dou Y, Ma Z, Tan H, Kodali K, Shaw T, Peng J, Smeyne RJ, Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo. Brain, 141(6):1753-1769(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: LRRK2, Parkinson’s disease, inflammation, LPS, microglia, cytokines.

Junmin Peng
contact affiliation	Structural Biology & Developmental Neurobiology Director, St. Jude Proteomics Facility St. Jude Children's Research Hospital 262 Danny Thomas Place, Memphis, TN 38105
contact email	Junmin.Peng@STJUDE.ORG
lab head
Timothy Shaw
contact affiliation	St Jude Children's Research Hospital
contact email	tim.shaw@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD006290

PRIDE project URI

• PRIDE
  1. PXD006290
     1. Label: PRIDE project
     2. Name: Cross talks between mutant Leucine Rich Repeat Kinase 2 in the peripheral immune system and the CNS regulate neurodegeneration after environmental insult - part 1