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PXD006289

PXD006289 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCross talks between mutant Leucine Rich Repeat Kinase 2 in the peripheral immune system and the CNS regulate neurodegeneration after environmental insult - part 2
DescriptionMissense mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene result in late-onset Parkinson’s disease (PD). The incomplete penetrance of LRRK2 mutations in humans and LRRK2 murine models of PD suggests that the disease may result from a complex interplay of genetic predispositions and persistent exogenous insults. To examine molecular pathways that might be affected by mutant LRRK2 in peripheral leukocytes, we performed mass spectrometry analysis (tandem mass tagging, TMT) on peripheral blood mononuclear cells obtained from intact and acute LPS-challenged WT and R1441G mutant mice.
HostingRepositoryPRIDE
AnnounceDate2018-05-03
AnnouncementXMLSubmission_2018-05-02_23:49:26.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTimothy Shaw
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-04-13 06:31:44ID requested
12018-05-02 23:49:26announced
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: LRRK2, Parkinson’s disease, inflammation, LPS
Contact List
Junmin Peng
contact affiliationStructural Biology & Developmental Neurobiology Director, St. Jude Proteomics Facility St. Jude Children's Research Hospital 262 Danny Thomas Place, Memphis, TN 38105
contact emailJunmin.Peng@STJUDE.ORG
lab head
Timothy Shaw
contact affiliationSt Jude Children's Research Hospital
contact emailtim.shaw@stjude.org
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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