PXD006211

PXD006211 is an original dataset announced via ProteomeXchange.

Title	Haloferax mediterranei
Description	We report the lysine acetylproteome of a model haloarchaeon, Haloferax mediterranei. Using Immunoaffinity enrichment, two-dimensional liquid chromatography (2D-LC) and Nano-LC-MS/MS analysis, we identified 1017 acetylation sites in 643 proteins, accounting for 17.3% of the total proteins in this haloarchaeon. Bioinformatics analysis indicated that lysine acetylation has a widespread subcellular distribution and participates in many biological processes, and protein interaction network analysis showed that lysine acetylation might also regulate a wide range of interactions. The proteins that are involved in translation and carbon metabolism consist of the preferred substrates of lysine acetylation. This dataset indicates that lysine acetylation is an abundant and diverse modification in H.mediterranei, providing opportunities to explore the physiological role of acetylation in this haloarchaeon.
HostingRepository	PRIDE
AnnounceDate	2017-08-07
AnnouncementXML	Submission_2017-08-07_01:45:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jingfang Liu
SpeciesList	scientific name: Halobacterium salinarum; NCBI TaxID: 2242;
ModificationList	acetylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-30 01:19:22	ID requested
⏵ 1	2017-08-07 01:45:10	announced

Liu J, Wang Q, Jiang X, Yang H, Zhao D, Han J, Luo Y, Xiang H, Systematic Analysis of Lysine Acetylation in the Halophilic Archaeon Haloferax mediterranei. J Proteome Res, 16(9):3229-3241(2017) [pubmed]

curator keyword: Biological

submitter keyword: Haloferax mediterranei,LC-MS/MS

Hua Xiang
contact affiliation	State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
contact email	xiangh@im.ac.cn
lab head
Jingfang Liu
contact affiliation	institute of microbiology
contact email	liujf@im.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD006211

PRIDE project URI

• PRIDE
  1. PXD006211
     1. Label: PRIDE project
     2. Name: Haloferax mediterranei