PXD006165

PXD006165 is an original dataset announced via ProteomeXchange.

Title	Mice liver tissue LC-MSMS EPAC
Description	We employed mouse models with targeted deletion of the genes encoding Epac1 (Rapgef3) and Epac2 (Rapgef4) in combination with 2/3 partial hepatectomy to investigate the functional roles of Epac1 and Epac2 in liver. Proteomic analysis of liver tissue before and 36h after hepatectomy revealed changes in the proteome in Epac depleted mice, most significantly of proteins involved in lipid metabolism. The current study is the first to identify functional roles for Epac1 and Epac2 in livers of an animal model. The results support the notion that Epac proteins are not required for normal liver development and function, but that these factors become important in the regulation of cellular responses in stressful situations.
HostingRepository	PRIDE
AnnounceDate	2019-09-12
AnnouncementXML	Submission_2019-09-30_00:50:41.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elise Aasebo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-24 05:05:55	ID requested
1	2019-09-12 01:38:33	announced
⏵ 2	2019-09-30 00:50:42	announced	2019-09-30: Updated publication reference for PubMed record(s): 31551444.

Sivertsen , Å, srud K, Pedersen L, Aesoy R, Muwonge H, Aaseb, ø E, Nitschke Pettersen IK, Herfindal L, Dobie R, Jenkins S, Berge RK, Henderson NC, Selheim F, D, ø, skeland SO, Bakke M, Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. Sci Rep, 9(1):13789(2019) [pubmed]

curator keyword: Biological

submitter keyword: Mice, liver tissue, LC-MSMS, EPAC, hepatectomy

Marit Bakke
contact affiliation	Department of Biomedicine, The University of Bergen, Bergen, Norway
contact email	marit.bakke@uib.no
lab head
Elise Aasebo
contact affiliation	PROBE
contact email	elise.aasebo@uib.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD006165

PRIDE project URI

• PRIDE
  1. PXD006165
     1. Label: PRIDE project
     2. Name: Mice liver tissue LC-MSMS EPAC