PXD006164

PXD006164 is an original dataset announced via ProteomeXchange.

Title	Comparison of control and Elmod1 knockout utricle extracts using tandem mass tagging
Description	Elmod1 knockout mice develop a severe inner ear defect beginning at early postnatal ages. Cuticular plates of utricle hair cells were initially formed normally, then degenerated after postnatal day 5 (P5). Similarly, hair bundles initially were formed normally, but the cell’s apical membrane subsequently lifted up; fused stereocilia were observed after P5. We used tandem mass tagging to determine whether there were any changes in medium- to high-abundance proteins in mutant animals. No statistically significant differences were seen in any protein quantified with two or more peptides.
HostingRepository	PRIDE
AnnounceDate	2018-10-24
AnnouncementXML	Submission_2018-10-24_14:48:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peter Barr-Gillespie
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-24 05:02:03	ID requested
⏵ 1	2018-10-24 14:48:29	announced

Krey JF, Dumont RA, Wilmarth PA, David LL, Johnson KR, Barr-Gillespie PG, ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci, 38(4):843-857(2018) [pubmed]

curator keyword: Biological

submitter keyword: Hair cells, vestibular, inner ear, actin, ARF6, ELMOD1, MYO6, PTPRQ

Peter Barr-Gillespie
contact affiliation	Oregon Hearing Research Center Oregon Health & Science University Portland OR 97239
contact email	gillespp@ohsu.edu
lab head
Peter Barr-Gillespie
contact affiliation	Oregon Hearing Research Center
contact email	gillespp@ohsu.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD006164
     1. Label: PRIDE project
     2. Name: Comparison of control and Elmod1 knockout utricle extracts using tandem mass tagging