PXD006164

PXD006164 is an original dataset announced via ProteomeXchange.

Title	Comparison of control and Elmod1 knockout utricle extracts using tandem mass tagging
Description	Elmod1 knockout mice develop a severe inner ear defect beginning at early postnatal ages. Cuticular plates of utricle hair cells were initially formed normally, then degenerated after postnatal day 5 (P5). Similarly, hair bundles initially were formed normally, but the cell’s apical membrane subsequently lifted up; fused stereocilia were observed after P5. We used tandem mass tagging to determine whether there were any changes in medium- to high-abundance proteins in mutant animals. No statistically significant differences were seen in any protein quantified with two or more peptides.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:34.305.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peter Barr-Gillespie
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-24 05:02:03	ID requested
1	2018-10-24 14:48:29	announced
⏵ 2	2024-10-22 04:04:42	announced	2024-10-22: Updated project metadata.

10.1523/JNEUROSCI.2658-17.2017;

Krey JF, Dumont RA, Wilmarth PA, David LL, Johnson KR, Barr-Gillespie PG, ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci, 38(4):843-857(2018) [pubmed]

curator keyword: Biological

submitter keyword: ARF6, inner ear, PTPRQ, vestibular, MYO6,Hair cells, actin, ELMOD1

Peter Barr-Gillespie
contact affiliation	Oregon Hearing Research Center Oregon Health & Science University Portland OR 97239
contact email	gillespp@ohsu.edu
lab head
Peter Barr-Gillespie
contact affiliation	Oregon Hearing Research Center
contact email	gillespp@ohsu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD006164

PRIDE project URI

• PRIDE
  1. PXD006164
     1. Label: PRIDE project
     2. Name: Comparison of control and Elmod1 knockout utricle extracts using tandem mass tagging