PXD006129 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Fiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier |
Description | Here we have shown that diet-mediated alterations of the gut microbiota composition cause an erosion of the colonic mucus barrier. A compensatory increase in cellular mucus production by the host is not sufficient to re-establish the barrier, possibly due to a lacking increase in mucus secretion. While microbial transplant from mice fed a fiber-rich diet can prevent the mucus defects, the mechanism seems to be independent of general fiber fermentation and rather depend on distinct bacterial species and/or their metabolites. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:04:48.636.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Liisa Arike |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-03-20 08:57:00 | ID requested | |
1 | 2017-12-22 00:58:07 | announced | |
2 | 2018-01-02 02:45:53 | announced | Updated publication reference for PubMed record(s): 29276171. |
⏵ 3 | 2024-10-22 04:04:52 | announced | 2024-10-22: Updated project metadata. |
Publication List
Schroeder BO, Birchenough GMH, St, å, hlman M, Arike L, Johansson MEV, Hansson GC, B, ä, ckhed F, Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration. Cell Host Microbe, 23(1):27-40.e7(2018) [pubmed] |
10.1016/j.chom.2017.11.004; |
Keyword List
curator keyword: Metaproteomics, Biological, Biomedical |
submitter keyword: Gut microbiota, obesity, fiber, mucus layer, metabolic disease, barrier function, Western diet, diet-microbe-host interaction |
Contact List
Liisa Arike |
contact affiliation | Liisa Arike, PhD Researcher Mucin Biology Group Department of Medical Biochemistry and Cell Biology University of Gothenburg Sweden |
contact email | liisaarike@gmail.com |
lab head | |
Liisa Arike |
contact affiliation | PhD |
contact email | liisaarike@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006129
- Label: PRIDE project
- Name: Fiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier