PXD006129

PXD006129 is an original dataset announced via ProteomeXchange.

Title	Fiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier
Description	Here we have shown that diet-mediated alterations of the gut microbiota composition cause an erosion of the colonic mucus barrier. A compensatory increase in cellular mucus production by the host is not sufficient to re-establish the barrier, possibly due to a lacking increase in mucus secretion. While microbial transplant from mice fed a fiber-rich diet can prevent the mucus defects, the mechanism seems to be independent of general fiber fermentation and rather depend on distinct bacterial species and/or their metabolites.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:48.636.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liisa Arike
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-20 08:57:00	ID requested
1	2017-12-22 00:58:07	announced
2	2018-01-02 02:45:53	announced	Updated publication reference for PubMed record(s): 29276171.
⏵ 3	2024-10-22 04:04:52	announced	2024-10-22: Updated project metadata.

Schroeder BO, Birchenough GMH, St, å, hlman M, Arike L, Johansson MEV, Hansson GC, B, ä, ckhed F, Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration. Cell Host Microbe, 23(1):27-40.e7(2018) [pubmed]

10.1016/j.chom.2017.11.004;

curator keyword: Metaproteomics, Biological, Biomedical

submitter keyword: Gut microbiota, obesity, fiber, mucus layer, metabolic disease, barrier function, Western diet, diet-microbe-host interaction

Liisa Arike
contact affiliation	Liisa Arike, PhD Researcher Mucin Biology Group Department of Medical Biochemistry and Cell Biology University of Gothenburg Sweden
contact email	liisaarike@gmail.com
lab head
Liisa Arike
contact affiliation	PhD
contact email	liisaarike@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/12/PXD006129

PRIDE project URI

• PRIDE
  1. PXD006129
     1. Label: PRIDE project
     2. Name: Fiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier