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PXD006129

PXD006129 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier
DescriptionHere we have shown that diet-mediated alterations of the gut microbiota composition cause an erosion of the colonic mucus barrier. A compensatory increase in cellular mucus production by the host is not sufficient to re-establish the barrier, possibly due to a lacking increase in mucus secretion. While microbial transplant from mice fed a fiber-rich diet can prevent the mucus defects, the mechanism seems to be independent of general fiber fermentation and rather depend on distinct bacterial species and/or their metabolites.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:04:48.636.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLiisa Arike
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-03-20 08:57:00ID requested
12017-12-22 00:58:07announced
22018-01-02 02:45:53announcedUpdated publication reference for PubMed record(s): 29276171.
32024-10-22 04:04:52announced2024-10-22: Updated project metadata.
Publication List
Schroeder BO, Birchenough GMH, St, å, hlman M, Arike L, Johansson MEV, Hansson GC, B, ä, ckhed F, Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration. Cell Host Microbe, 23(1):27-40.e7(2018) [pubmed]
10.1016/j.chom.2017.11.004;
Keyword List
curator keyword: Metaproteomics, Biological, Biomedical
submitter keyword: Gut microbiota, obesity, fiber, mucus layer, metabolic disease, barrier function, Western diet, diet-microbe-host interaction
Contact List
Liisa Arike
contact affiliationLiisa Arike, PhD Researcher Mucin Biology Group Department of Medical Biochemistry and Cell Biology University of Gothenburg Sweden
contact emailliisaarike@gmail.com
lab head
Liisa Arike
contact affiliationPhD
contact emailliisaarike@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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