PXD006122

PXD006122 is an original dataset announced via ProteomeXchange.

Title	Proteomics on post-mortem human brain tissue of patients with Alzheimer`s, Parkinson`s and Lewy body dementias.
Description	We have used HiRIEF (High Resolution Isoelectric Focusing) LC-MS proteomics with isobaric tags (TMT10plex) to compare 32 post-mortem human brains in the prefrontal cortex (Brodmann area 9) of prospectively followed patients with Alzheimer`s disease (AD), Parkinson`s disease with dementia (PDD), dementia with Lewy bodies (DLB) and older adults without dementia.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:42.009.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Branca
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-20 04:54:30	ID requested
1	2017-12-08 01:19:23	announced
2	2018-04-06 07:06:57	announced	Updated publication reference for PubMed record(s): 29324989.
⏵ 3	2024-10-22 04:04:46	announced	2024-10-22: Updated project metadata.

Bereczki E, Branca RM, Francis PT, Pereira JB, Baek JH, Hortob, á, gyi T, Winblad B, Ballard C, Lehti, ö J, Aarsland D, Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach. Brain, 141(2):582-595(2018) [pubmed]

10.1093/brain/awx352;

curator keyword: Biomedical

submitter keyword: synaptic, Lewy body, proteomics, brain, prefrontal cortex, Alzheimer, Brodmann area 9, Parkinson, HiRIEF, LCMS,human

Janne Lehtiö
contact affiliation	Department of Oncology-Pathology, Karolinska Institutet and Science for Life Laboratory, Stockholm, Sweden
contact email	janne.lehtio@ki.se
lab head
Rui Branca
contact affiliation	Clinical Proteomics Unit, Dep. of Oncology-Pathology
contact email	rui.mamede-branca@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/12/PXD006122

PRIDE project URI

• PRIDE
  1. PXD006122
     1. Label: PRIDE project
     2. Name: Proteomics on post-mortem human brain tissue of patients with Alzheimer`s, Parkinson`s and Lewy body dementias.