PXD006114

PXD006114 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics of in vivo resistance to EGFR-targeted therapy in lung cancer cells
Description	Mass spectrometry-based quantitative proteomics profiling of in vivo signaling changes in 41 therapy resistant (osimertinib or EGFR/Met bispecific antibody treament) tumors from four xenograft NSCLC models.
HostingRepository	PRIDE
AnnounceDate	2017-08-28
AnnouncementXML	Submission_2017-08-28_02:19:37.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD006114
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kristina Bennet Emdal
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-20 02:39:37	ID requested
⏵ 1	2017-08-28 02:19:38	announced

Emdal KB, Dittmann A, Reddy RJ, Lescarbeau RS, Moores SL, Laquerre S, White FM, Resistance to Osimertinib and JNJ-61186372, an EGFR/Met Bispecific Antibody, Reveals Unique and Consensus Mechanisms of Resistance. Mol Cancer Ther, 16(11):2572-2585(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: NSCLC, EGFR, xenografts, drug resistance, tyrosine phosphorylation, mass spectrometry

Forest White
contact affiliation	Massachusetts Institute of Technology
contact email	fwhite@mit.edu
lab head
Kristina Bennet Emdal
contact affiliation	Massachusetts Institute of Technology
contact email	kbemdal@mit.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD006114

PRIDE project URI

• PRIDE
  1. PXD006114
     1. Label: PRIDE project
     2. Name: Phosphoproteomics of in vivo resistance to EGFR-targeted therapy in lung cancer cells