PXD006103 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Effect of Sec61 inhibitor mycolactone on the proteome of the MutuDC dendritic cell line |
Description | Here we used a newly identified Sec61 blocker, mycolactone, to analyze Sec61 contribution to antigen cross presentation, ERAD and transport of internalized antigens into the cytosol in dendritic cells. Shotgun proteomics were used to asses the broad-ranging effects of Sec61 blockade on dendritic cells and its effect on critical proteins required for antigen presentation and ERAD. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:04:44.902.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jean-David Morel |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | L-methionine sulfoxide; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-03-16 04:25:41 | ID requested | |
1 | 2017-07-11 04:39:09 | announced | |
2 | 2018-06-26 08:31:12 | announced | Updated publication reference for PubMed record(s): 29915147, 28679634. |
⏵ 3 | 2024-10-22 04:04:55 | announced | 2024-10-22: Updated project metadata. |
Publication List
Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C, Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export. Proc Natl Acad Sci U S A, 114(29):E5910-E5919(2017) [pubmed] |
10.1073/pnas.1705242114; |
Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Mac, é L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C, Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature. Mol Cell Proteomics, 17(9):1750-1765(2018) [pubmed] |
10.1074/mcp.ra118.000824; |
Keyword List
submitter keyword: Mouse MutuDC dendritic mycolactone Sec61 MS/MS LFQ |
Contact List
Caroline DEMANGEL |
contact affiliation | Institut Pasteur, Immunobiology of Infection Unit, 75015 Paris, France |
contact email | caroline.demangel@pasteur.fr |
lab head | |
Jean-David Morel |
contact affiliation | Institut Pasteur, Paris, France |
contact email | jean-david.morel@pasteur.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006103
- Label: PRIDE project
- Name: Effect of Sec61 inhibitor mycolactone on the proteome of the MutuDC dendritic cell line