PXD006081

PXD006081 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry analysis of cleavage sites for different protease allergens in human IL-33
Description	The cytokine interleukin-33 (IL-33) is an epithelial alarmin with critical roles in allergic inflammation and type 2 immunity. The project aims at the characterization of the direct cleavage of IL-33 by allergen proteases, resulting in its activation, and in the subsequent induction of type 2 cytokine production in group 2 innate lymphoid cells. The present dataset contains mass spectrometry analyses to map the cleavage sites for 9 distinct allergens proteases in the human IL-33 sequence.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:08:53.101.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anne Gonzalez de Peredo
SpeciesList	scientific name: Oryctolagus cuniculus (Rabbit); NCBI TaxID: 9986; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-13 03:57:31	ID requested
1	2018-03-14 01:49:56	announced
2	2018-03-26 00:31:31	announced	Updated publication reference for PubMed record(s): 29556000.
⏵ 3	2024-10-22 04:08:53	announced	2024-10-22: Updated project metadata.

Cayrol C, Duval A, Schmitt P, Roga S, Camus M, Stella A, Burlet-Schiltz O, Gonzalez-de-Peredo A, Girard JP, Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33. Nat Immunol, 19(4):375-385(2018) [pubmed]

10.1038/s41590-018-0067-5;

curator keyword: Biomedical

submitter keyword: peptide mapping,Interleukin-33, human, protease processing, LC-MS/MS

odile Schiltz
contact affiliation	Institute of Pharmacology and Structural Biology, CNRS, University of Toulouse
contact email	Odile.Schiltz@ipbs.fr
lab head
Anne Gonzalez de Peredo
contact affiliation	CNRS/IPBS
contact email	gonzalez@ipbs.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/03/PXD006081

PRIDE project URI

• PRIDE
  1. PXD006081
     1. Label: PRIDE project
     2. Name: Mass spectrometry analysis of cleavage sites for different protease allergens in human IL-33