PXD006079

PXD006079 is an original dataset announced via ProteomeXchange.

Title	Composite PRC1/dBRD4/MOZ/MORF protein complexes in Drosophila
Description	In this project, we provide strong proteomic evidence for PcG interaction with classic co-activators, BRD4 and MOZ/MORF, captured on chromatin during embryogenesis in Drosophila, leading to a model in which developmental regulatory elements are universally ‘poised’ early in development via occupancy of composite protein complexes of PcG silencing proteins and classical co-activators. These bivalent protein interactions may resolve into full activation or repression, depending on the cell type-specific expression, binding, and function of transcription factors.
HostingRepository	PRIDE
AnnounceDate	2017-11-02
AnnouncementXML	Submission_2017-11-02_04:43:02.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Barry Zee
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	monohydroxylated residue
Instrument	LTQ; LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-13 03:06:08	ID requested
⏵ 1	2017-11-02 04:43:03	announced

Kang H, Jung YL, McElroy KA, Zee BM, Wallace HA, Woolnough JL, Park PJ, Kuroda MI, . Genes Dev, 31(19):1988-2002(2017) [pubmed]

curator keyword: Biological

submitter keyword: Drosophila, BioTAP-XL, formaldehyde crosslinking

Mitzi Kuroda
contact affiliation	Department of Genetics, Harvard Medical School Division of Genetics, Brigham and Women's Hospital Boston MA USA
contact email	mkuroda@genetics.med.harvard.edu
lab head
Barry Zee
contact affiliation	Harvard Medical School
contact email	bzee@genetics.med.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/11/PXD006079

PRIDE project URI

• PRIDE
  1. PXD006079
     1. Label: PRIDE project
     2. Name: Composite PRC1/dBRD4/MOZ/MORF protein complexes in Drosophila