PXD006015 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SILAC pulse labeling in HGPS fibroblasts - WT samples |
Description | Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectrometry to investigate nuclear protein homeostasis in primary HGPS-derived cells. |
HostingRepository | PRIDE |
AnnounceDate | 2017-07-07 |
AnnouncementXML | Submission_2017-07-07_08:51:52.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Abby Buchwalter |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-03-03 09:26:42 | ID requested | |
⏵ 1 | 2017-07-07 08:51:52 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: human progeria SILAC wild type controls |
Contact List
Martin W. Hetzer |
contact affiliation | Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037 |
contact email | hetzer@salk.edu |
lab head | |
Abby Buchwalter |
contact affiliation | The Salk Institute for Biological Studies |
contact email | abuchwalter@salk.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD006015 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006015
- Label: PRIDE project
- Name: SILAC pulse labeling in HGPS fibroblasts - WT samples