PXD006013 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SILAC analysis of relative protein abundance in nuclei - PRF168 and PRF167 |
Description | Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectrometry to investigate nuclear protein abundance in primary HGPS-derived cells. |
HostingRepository | PRIDE |
AnnounceDate | 2017-07-07 |
AnnouncementXML | Submission_2017-07-07_08:41:26.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD006013 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Abby Buchwalter |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 6x(13)C: 4x(15)N labeled L-arginine; 6x(13)C labeled residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-03-03 09:08:16 | ID requested | |
⏵ 1 | 2017-07-07 08:41:27 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: human progeria SILAC |
Contact List
Martin W. Hetzer |
contact affiliation | Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037 |
contact email | hetzer@salk.edu |
lab head | |
Abby Buchwalter |
contact affiliation | The Salk Institute for Biological Studies |
contact email | abuchwalter@salk.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006013
- Label: PRIDE project
- Name: SILAC analysis of relative protein abundance in nuclei - PRF168 and PRF167