PXD006012

PXD006012 is an original dataset announced via ProteomeXchange.

Title	SILAC analysis of relative protein abundance in nuclei - AG3258 and AG11498
Description	Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectrometry to investigate nuclear protein abundance in primary HGPS-derived cells.
HostingRepository	PRIDE
AnnounceDate	2017-07-07
AnnouncementXML	Submission_2017-07-07_08:39:34.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD006012
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Abby Buchwalter
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C: 4x(15)N labeled L-arginine; phosphorylated residue; 6x(13)C labeled residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-03 08:54:41	ID requested
⏵ 1	2017-07-07 08:39:35	announced

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: human progeria SILAC

Martin W. Hetzer
contact affiliation	Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037
contact email	hetzer@salk.edu
lab head
Abby Buchwalter
contact affiliation	The Salk Institute for Biological Studies
contact email	abuchwalter@salk.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD006012

PRIDE project URI

• PRIDE
  1. PXD006012
     1. Label: PRIDE project
     2. Name: SILAC analysis of relative protein abundance in nuclei - AG3258 and AG11498