PXD006009

PXD006009 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analyses of budding yeast cells harboring an additional chromosome
Description	Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down Syndrome and cancer. Allelic variances have been thought to be the sole cause of this heterogeneity. Here, we systematically examine the consequences of gaining and losing single or multiple chromosomes to show that the aneuploid state causes non-genetic phenotypic variability. Yeast cell populations harboring the same defined aneuploidy exhibit heterogeneity in cell cycle progression and response to environmental perturbations, which we show to be partly due to gene copy number imbalances. Thus, subtle changes in gene expression severely impact the robustness of biological networks and cause alternate behaviors when they occur at a large scale. Because trisomic mice also exhibit variable phenotypes, we further propose that non-genetic individuality is a universal characteristic of the aneuploid state that could contribute to variability in presentation and treatment responses of diseases caused by aneuploidy.
HostingRepository	PRIDE
AnnounceDate	2017-04-10
AnnouncementXML	Submission_2017-04-10_01:53:36.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD006009
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Amanda Del Rosario
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	TMT6plex; Oxidation
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-03 02:25:21	ID requested
⏵ 1	2017-04-10 01:53:37	announced

Beach RR, Ricci-Tam C, Brennan CM, Moomau CA, Hsu PH, Hua B, Silberman RE, Springer M, Amon A, Aneuploidy Causes Non-genetic Individuality. Cell, 169(2):229-242.e21(2017) [pubmed]

curator keyword: Biological

submitter keyword: LC-MS/MS, yeast, aneuploid

Amanda M Del Rosario
contact affiliation	Massachusetts Institute of Technology
contact email	aweaver@mit.edu
lab head
Amanda Del Rosario
contact affiliation	Massachusetts Institute of Technology
contact email	aweaver@mit.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD006009
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analyses of budding yeast cells harboring an additional chromosome