PXD006006

PXD006006 is an original dataset announced via ProteomeXchange.

Title	Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer
Description	We used quantitative (phospho)proteomics to study how cells may escape the activity of RET kinase inhibitors.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:08:03.559.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	René Zahedi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-03 02:05:48	ID requested
1	2017-06-21 02:47:01	announced
⏵ 2	2024-10-22 04:08:04	announced	2024-10-22: Updated project metadata.

10.1126/scitranslmed.aah6144;

Plenker D, Riedel M, Br, ä, gelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, B, ü, hrmann M, Pagel O, Tischler V, Scheel AH, Sch, ü, tte D, Song Y, Stark J, Mrugalla F, Alber Y, Richters A, Engel J, Leenders F, Heuckmann JM, Wolf J, Diebold J, Pall G, Peifer M, Aerts M, Gevaert K, Zahedi RP, Buettner R, Shokat KM, McDonald NQ, Kast SM, Gautschi O, Thomas RK, Sos ML, Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Sci Transl Med, 9(394):(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: phosphoproteome, TMT,Kinase inhibitor, proteome

René Zahedi
contact affiliation	ISAS Otto-Hahn-Str. 6b 44227 Dortmund Germany
contact email	zahedi@isas.de
lab head
René Zahedi
contact affiliation	Segal Cancer Proteomics Centre
contact email	Rene.Zahedi@ladydavis.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/06/PXD006006

PRIDE project URI

• PRIDE
  1. PXD006006
     1. Label: PRIDE project
     2. Name: Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer