PXD005985

PXD005985 is an original dataset announced via ProteomeXchange.

Title	SILAC proteomics analysis to discover effect sensors of EGFR inhibition
Description	Targeted therapies against EGFR show clinical benefit, but resistance to these agents invariably develops. Thus, there is a need for dynamic biomarkers - effect sensors - that reflect treatment with EGFR therapeutics during therapy. Making use of SILAC-labeling we aimed to discover plasma membrane proteins that become differentially expressed after treatment with EGFR inhibitor erlotinib in three erlotinib-sensitive breast cancer cell lines.
HostingRepository	PRIDE
AnnounceDate	2018-10-18
AnnouncementXML	Submission_2018-10-17_22:10:02.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rolf de Boer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C labeled residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2017-02-28 01:50:15	ID requested
⏵ 1	2018-10-17 22:10:03	announced

de Boer HR, Pool M, Joosten E, Everts M, Samplonius DF, Helfrich W, Groen HJM, van Cooten S, Fusetti F, Fehrmann RSN, de Vries EGE, van Vugt MATM, Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition. Oncogene, 38(9):1477-1488(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: EGFR SILAC Breast cancer biomarkers erlotinib

Marcel A.T.M. van Vugt
contact affiliation	Medical Oncology University Medical Center Groningen Groningen
contact email	m.vugt@umcg.nl
lab head
Rolf de Boer
contact affiliation	University Medical Center Groningen
contact email	h.r.de.boer@umcg.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD005985

PRIDE project URI

• PRIDE
  1. PXD005985
     1. Label: PRIDE project
     2. Name: SILAC proteomics analysis to discover effect sensors of EGFR inhibition