PXD005981

PXD005981 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Tailoring protein nanomechanics with chemical reactivity
Description	The nanomechanical properties of elastomeric proteins determine the elasticity of a variety of tissues where modifications present at the covalent disulfide bonds can enhance protein stiffness. We propose an alternative chemical route to promote non-enzymatic oxidative protein folding via disulfide isomerization. Mass spectrometery has been used to determine the dynamics of S-thiolation and its role in modulating protein nanomechanics.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:36:18.226.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005981
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Steven Lynham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Hex; Cysteinyl
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-02-27 07:51:07	ID requested
1	2018-10-26 09:26:49	announced
⏵ 2	2024-10-22 04:36:21	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/ncomms15658;
Beedle AEM, Mora M, Lynham S, Stirnemann G, Garcia-Manyes S, Tailoring protein nanomechanics with chemical reactivity. Nat Commun, 8():15658(2017) [pubmed]
10.6019/PXD005981;

10.1038/ncomms15658;

Beedle AEM, Mora M, Lynham S, Stirnemann G, Garcia-Manyes S, Tailoring protein nanomechanics with chemical reactivity. Nat Commun, 8():15658(2017) [pubmed]

10.6019/PXD005981;

Keyword List

curator keyword: Biological
submitter keyword: LC-MS/MS, cysteine modifications

curator keyword: Biological

submitter keyword: LC-MS/MS, cysteine modifications

Contact List

Sergi Garcia-Manyes
contact affiliation	Professor of Biophysics, Department of Physics & Randall Division of Cell and Molecular Biophysics, King's College London
contact email	sergi.garcia-manyes@kcl.ac.uk
lab head
Steven Lynham
contact affiliation	King's College London
contact email	steven.lynham@kcl.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD005981
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD005981

PRIDE project URI

Repository Record List

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