PXD005949

PXD005949 is an original dataset announced via ProteomeXchange.

Title	Large-scale HDMSE mapping of the normal sputum proteome
Description	Severe asthma is a collection of disease entities with varying pathophysiological characteristics that result in symptoms of cough, wheeze and breathlessness, with frequent exacerbations. To address the problem of phenotypic difference and heterogeneity, the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project was set up as a public-private partnership within the framework of the Innovative Medicines Initiative (IMI), engaging academia, the pharmaceutical industry and patient groups. The goal of this investigation was to identify proteomic fingerprints in induced sputum that characterize patients with severe asthma and to determine whether subgroups of severe asthmatics can be identified. Furthermore, we were interested in elucidating the biological pathways that showed differences between subgroups. This dataset is a description of the normal sputum proteome.
HostingRepository	PRIDE
AnnounceDate	2018-05-14
AnnouncementXML	Submission_2018-05-14_03:05:59.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005949
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Paul Skipp
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Carbamidomethyl
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2017-02-22 03:18:31	ID requested
⏵ 1	2018-05-14 03:06:00	announced

Burg D, Schofield JPR, Brandsma J, Staykova D, Folisi C, Bansal A, Nicholas B, Xian Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Fleming L, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Hashimoto S, Horv, á, th I, Howarth P, Krug N, Montuschi P, Sanak M, Sandstr, ö, m T, Singer F, Sun K, Pandis I, Auffray C, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Djukanovi, ć R, Skipp PJ, The U-Biopred Study Group, Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome. J Proteome Res, 17(6):2072-2091(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Sputum, Label free, Data independent, Human

Paul J S Skipp
contact affiliation	Centre for Proteomic Research, Biological Sciences, University of Southampton
contact email	pjss@soton.ac.uk
lab head
Paul Skipp
contact affiliation	Centre for Proteomic Research, University of Southampton
contact email	pjss@soton.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD005949

PRIDE project URI

• PRIDE
  1. PXD005949
     1. Label: PRIDE project
     2. Name: Large-scale HDMSE mapping of the normal sputum proteome