PXD005911

PXD005911 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteome of RA-responsive and RA-resistant breast cancer cell lines
Description	Retinoic acid (RA), the main active vitamin A metabolite, controls multiple biological processes such as cell proliferation and differentiation through genomic programs and kinase cascades activation. Due to these properties, RA has proven anti-cancer capacity. Several breast cancer cells respond to the antiproliferative effects of RA, while others are RA-resistant. However, the overall signaling and transcriptional pathways that are altered in such cells have not been elucidated. Here, in a large-scale analysis of the phosphoproteins and in a genome-wide analysis of the RA-regulated genes, we compared two human breast cancer cell lines, a RA-responsive one, the MCF7 cell line, and a RA-resistant one, the BT474 cell line, which depicts several alterations of the "kinome".
HostingRepository	PRIDE
AnnounceDate	2020-10-15
AnnouncementXML	Submission_2020-10-14_23:35:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc Negroni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-02-10 09:14:42	ID requested
⏵ 1	2020-10-14 23:35:02	announced

Carrier M, Joint M, Lutzing R, Page A, Rochette-Egly C, Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One, 11(6):e0157290(2016) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Retinoic acid

phosphorylation

phosphoproteome

Breast Cancer

gene expression

RNA-Seq

Cecile Rochette-Egly
contact affiliation	Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, FRANCE
contact email	cecile.rochette-egly@igbmc.fr
lab head
Luc Negroni
contact affiliation	CNRS
contact email	luc.negroni@igbmc.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD005911

PRIDE project URI

• PRIDE
  1. PXD005911
     1. Label: PRIDE project
     2. Name: Phosphoproteome of RA-responsive and RA-resistant breast cancer cell lines