PXD005873 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Systemic perturbation of keratinocyte homeostasis |
Description | We performed comprehensive proteome profiling (ECM and cell lysate) of human collagen VII deficient and control epidermal keratinocytes to generate global and detailed images of dysregulated epidermal molecular pathways linked to loss of collagen VII. These revealed downregulation of interaction partners of collagen VII, but also increased abundance of S100 pro-inflammatory proteins and enhanced activity of lysosomal proteases. Thus, loss of a single extracellular structural protein, collagen VII, induced persistent fibrosis enabling inflammatory and tissue destabilizing activities of keratinocytes. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:36:10.996.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joern Dengjel |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-02-08 00:00:11 | ID requested | |
1 | 2018-01-16 02:26:45 | announced | |
2 | 2020-04-21 22:34:15 | announced | 2020-04-22: Updated publication reference for PubMed record(s): 32305317, 29326176. |
⏵ 3 | 2024-10-22 04:36:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1016/j.jid.2020.02.040; |
10.1074/mcp.ra117.000437; |
Berberich B, Thriene K, Gretzmeier C, K, ü, hl T, Bayer H, Athanasiou I, Rafei-Shamsabadi DA, Bruckner-Tuderman L, Nystr, ö, m A, Kiritsi D, Dengjel J, Proteomic Profiling of Fibroblasts Isolated from Chronic Wounds Identifies Disease-Relevant Signaling Pathways. J Invest Dermatol, 140(11):2280-2290.e4(2020) [pubmed] |
Thriene K, Gr, ü, ning BA, Bornert O, Erxleben A, Leppert J, Athanasiou I, Weber E, Kiritsi D, Nystr, ö, m A, Reinheckel T, Backofen R, Has C, Bruckner-Tuderman L, Dengjel J, Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes. Mol Cell Proteomics, 17(4):565-579(2018) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: ECM, keratinocyte, matrix, LC-MS, SILAC, collagen,human |
Contact List
Joern Dengjel |
contact affiliation | Dep. of Biology, University of Fribourg, Switzerland |
contact email | joern.dengjel@unifr.ch |
lab head | |
Joern Dengjel |
contact affiliation | University of Fribourg |
contact email | joern.dengjel@medizin.uni-freiburg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD005873 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005873
- Label: PRIDE project
- Name: Systemic perturbation of keratinocyte homeostasis