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PXD005873

PXD005873 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSystemic perturbation of keratinocyte homeostasis
DescriptionWe performed comprehensive proteome profiling (ECM and cell lysate) of human collagen VII deficient and control epidermal keratinocytes to generate global and detailed images of dysregulated epidermal molecular pathways linked to loss of collagen VII. These revealed downregulation of interaction partners of collagen VII, but also increased abundance of S100 pro-inflammatory proteins and enhanced activity of lysosomal proteases. Thus, loss of a single extracellular structural protein, collagen VII, induced persistent fibrosis enabling inflammatory and tissue destabilizing activities of keratinocytes.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:36:10.996.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJoern Dengjel
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-02-08 00:00:11ID requested
12018-01-16 02:26:45announced
22020-04-21 22:34:15announced2020-04-22: Updated publication reference for PubMed record(s): 32305317, 29326176.
32024-10-22 04:36:26announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.jid.2020.02.040;
10.1074/mcp.ra117.000437;
Berberich B, Thriene K, Gretzmeier C, K, ü, hl T, Bayer H, Athanasiou I, Rafei-Shamsabadi DA, Bruckner-Tuderman L, Nystr, ö, m A, Kiritsi D, Dengjel J, Proteomic Profiling of Fibroblasts Isolated from Chronic Wounds Identifies Disease-Relevant Signaling Pathways. J Invest Dermatol, 140(11):2280-2290.e4(2020) [pubmed]
Thriene K, Gr, ü, ning BA, Bornert O, Erxleben A, Leppert J, Athanasiou I, Weber E, Kiritsi D, Nystr, ö, m A, Reinheckel T, Backofen R, Has C, Bruckner-Tuderman L, Dengjel J, Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes. Mol Cell Proteomics, 17(4):565-579(2018) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: ECM, keratinocyte, matrix, LC-MS, SILAC, collagen,human
Contact List
Joern Dengjel
contact affiliationDep. of Biology, University of Fribourg, Switzerland
contact emailjoern.dengjel@unifr.ch
lab head
Joern Dengjel
contact affiliationUniversity of Fribourg
contact emailjoern.dengjel@medizin.uni-freiburg.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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