PXD005823 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative proteomic analysis and bioluminescent reporter gene assays to investigate effects of simulated microgravity on Caco-2 cells |
Description | Microgravity is one of the most important features in spaceflight. Previous evidence has shown that significant changes to the musculoskeletal and immune systems occurred under microgravity. The present study was undertaken to explore the change in protein abundance in human colon colorectal cells that were incubated for 48 or 72 h either in normal conditions and µG simulated conditions. The comparative proteomic method based on the 18O labeling technique was applied to investigate the up-regulated proteins and down-regulated proteins in SH-SY5Y under simulated microgravity. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:36:07.720.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Riccardo Zenezini Chiozzi |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-02-01 01:18:26 | ID requested | |
1 | 2017-07-26 04:15:40 | announced | |
⏵ 2 | 2024-10-22 04:36:09 | announced | 2024-10-22: Updated project metadata. |
Publication List
La Barbera G, Capriotti AL, Michelini E, Piovesana S, Calabretta MM, Zenezini Chiozzi R, Roda A, Lagan, à A, Proteomic analysis and bioluminescent reporter gene assays to investigate effects of simulated microgravity on Caco-2 cells. Proteomics, 17(15-16):(2017) [pubmed] |
10.1002/pmic.201700081; |
Keyword List
curator keyword: Biological |
submitter keyword: simulated microgravity, Nuclear factor κ-B,Caco-2 cells, reporter gene technology, Label-free proteomics, bioluminescence |
Contact List
Aldo Laganà |
contact affiliation | 1Dipartimento di Chimica, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy |
contact email | aldo.lagana@uniroma1.it |
lab head | |
Riccardo Zenezini Chiozzi |
contact affiliation | university la Sapienza, Roma |
contact email | riccardo.zenezini@uniroma1.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005823
- Label: PRIDE project
- Name: Comparative proteomic analysis and bioluminescent reporter gene assays to investigate effects of simulated microgravity on Caco-2 cells