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PXD005823

PXD005823 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative proteomic analysis and bioluminescent reporter gene assays to investigate effects of simulated microgravity on Caco-2 cells
DescriptionMicrogravity is one of the most important features in spaceflight. Previous evidence has shown that significant changes to the musculoskeletal and immune systems occurred under microgravity. The present study was undertaken to explore the change in protein abundance in human colon colorectal cells that were incubated for 48 or 72 h either in normal conditions and µG simulated conditions. The comparative proteomic method based on the 18O labeling technique was applied to investigate the up-regulated proteins and down-regulated proteins in SH-SY5Y under simulated microgravity.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:36:07.720.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRiccardo Zenezini Chiozzi
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-02-01 01:18:26ID requested
12017-07-26 04:15:40announced
22024-10-22 04:36:09announced2024-10-22: Updated project metadata.
Publication List
La Barbera G, Capriotti AL, Michelini E, Piovesana S, Calabretta MM, Zenezini Chiozzi R, Roda A, Lagan, à A, Proteomic analysis and bioluminescent reporter gene assays to investigate effects of simulated microgravity on Caco-2 cells. Proteomics, 17(15-16):(2017) [pubmed]
10.1002/pmic.201700081;
Keyword List
curator keyword: Biological
submitter keyword: simulated microgravity, Nuclear factor κ-B,Caco-2 cells, reporter gene technology, Label-free proteomics, bioluminescence
Contact List
Aldo Laganà
contact affiliation1Dipartimento di Chimica, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy
contact emailaldo.lagana@uniroma1.it
lab head
Riccardo Zenezini Chiozzi
contact affiliationuniversity la Sapienza, Roma
contact emailriccardo.zenezini@uniroma1.it
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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